{"id":"W1512020770","doi":"10.1002/adsc.201500189","title":"Arene <i>cis</i>‐Diol Dehydrogenase‐Catalysed Regio‐ and Stereoselective Oxidation of Arene‐, Cycloalkane‐ and Cycloalkene‐<i>cis</i>‐diols to Yield Catechols and Chiral α‐Ketols","year":2015,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Chemistry; Enantiopure drug; Regioselectivity; Stereoselectivity; Diol; Cycloalkane; Naphthalene; Kinetic resolution; Stereochemistry; Dehydrogenase; Organic chemistry; Medicinal chemistry; Catalysis; Enzyme; Enantioselective synthesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007526363,0.0002764537,0.00009688934,0.0001258542,0.00006099943,0.0002164031,0.0001589166,0.00009738286,0.0009780807],"category_scores_gemma":[0.00005887815,0.0001045159,0.0001489918,0.0001316868,0.0001638936,0.0001755932,0.00009862833,0.000281228,0.0002854077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002820669,"about_ca_system_score_gemma":0.0001709331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387985,"about_ca_topic_score_gemma":0.001265595,"domain_scores_codex":[0.9999372,0.000005046054,0.000003338302,0.00001491465,0.00002159169,0.00001795466],"domain_scores_gemma":[0.9999608,0.000005862137,0.000009303743,0.000006139941,0.000009504757,0.000008425062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000176057,0.000004899717,0.00008189781,0.000007680483,8.690341e-7,0.00001578014,0.000005838274,0.0000202238,0.9992323,0.00006829049,0.00001805637,0.0005265914],"study_design_scores_gemma":[0.000001213475,0.00001470058,0.0005293607,6.526699e-7,0.000001327648,0.00004333318,0.000007195008,0.0001456589,0.9988058,0.00001603783,0.0004335685,0.000001221385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837039,0.000351188,0.010423,0.000110805,0.0000328265,0.00002530971,0.0005859542,0.0001610485,0.004605845],"genre_scores_gemma":[0.987228,0.0006132302,0.006048181,0.0000309637,0.000003848847,0.00001620056,0.0007960551,0.0000484616,0.005215112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001387985,"threshold_uncertainty_score":0.003271997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01555915355444772,"score_gpt":0.2464911738852219,"score_spread":0.2309320203307742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}