{"id":"W1512020770","doi":"10.1002/adsc.201500189","title":"Arene <i>cis</i>‐Diol Dehydrogenase‐Catalysed Regio‐ and Stereoselective Oxidation of Arene‐, Cycloalkane‐ and Cycloalkene‐<i>cis</i>‐diols to Yield Catechols and Chiral α‐Ketols","year":2015,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Chemistry; Enantiopure drug; Regioselectivity; Stereoselectivity; Diol; Cycloalkane; Naphthalene; Kinetic resolution; Stereochemistry; Dehydrogenase; Organic chemistry; Medicinal chemistry; Catalysis; Enzyme; Enantioselective synthesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004666719,0.0004469199,0.0007334343,0.0002721337,0.0001432164,0.00007030022,0.0002464846,0.0002468188,0.000005122694],"category_scores_gemma":[0.001314294,0.0004338087,0.0001322588,0.000538038,0.0001978721,0.0000764258,0.0002595721,0.00010818,0.000003794728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004538239,"about_ca_system_score_gemma":0.00007626072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125185,"about_ca_topic_score_gemma":0.0002372065,"domain_scores_codex":[0.9975031,0.0001194123,0.0006168798,0.001047782,0.0003104035,0.0004024458],"domain_scores_gemma":[0.9979448,0.0001587643,0.000368518,0.0008150772,0.0003292731,0.0003835829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003183142,0.00009585611,0.002055199,0.00005644098,0.0002984831,0.000002617824,0.0002968588,0.0001928605,0.9879836,0.00002126631,0.0001442811,0.008534161],"study_design_scores_gemma":[0.0005120321,0.0003651156,0.00117492,0.0001198521,0.0004013154,0.00003427614,0.0005661985,0.00004715154,0.9953172,0.0001602571,0.0008089545,0.000492754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914778,0.003651352,0.003786708,0.0001245935,0.00003793966,0.0005548925,0.0001070938,0.00003061022,0.0002289781],"genre_scores_gemma":[0.9955167,0.001309626,0.001926603,0.0001802889,0.00007726839,0.0002249455,0.0004884622,0.00005844944,0.0002176242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008041408,"threshold_uncertainty_score":0.9998114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01555915355444772,"score_gpt":0.2464911738852219,"score_spread":0.2309320203307742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}