{"id":"W1512068531","doi":"10.1002/stem.1721","title":"Molecular Evidence for OCT4-Induced Plasticity in Adult Human Fibroblasts Required for Direct Cell Fate Conversion to Lineage Specific Progenitors","year":2014,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Reprogramming; Biology; Cell biology; Progenitor cell; Cell fate determination; Induced pluripotent stem cell; Cellular differentiation; Progenitor; Stem cell; Embryonic stem cell; Cell; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000897,0.0001983457,0.00006595886,0.0001835303,0.0001130918,0.000208738,0.0001029411,0.0001491626,0.001542263],"category_scores_gemma":[0.0001309497,0.0001074853,0.0001610582,0.0000743124,0.0001122456,0.0001382404,0.0001108317,0.0002429406,0.0002949988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001360734,"about_ca_system_score_gemma":0.0001457914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004331822,"about_ca_topic_score_gemma":0.0005644711,"domain_scores_codex":[0.9999164,0.00001406175,0.00001055129,0.00001377531,0.0000270992,0.0000180763],"domain_scores_gemma":[0.9998814,0.00003361566,0.00002852127,0.00001932511,0.00001256669,0.00002465238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001817563,0.000005666274,0.0001952193,0.000007825464,0.000001513727,0.00004931776,0.000003049813,0.00001890742,0.9992256,0.00004705965,0.000005770284,0.0004217312],"study_design_scores_gemma":[0.000004244363,0.00008244708,0.006572773,0.000002082769,0.000006910653,0.000440189,0.00001372782,0.0003331985,0.9917505,0.00003465352,0.0007575246,0.000001635962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927019,0.0004797014,0.004292018,0.00006194256,0.00001077659,0.000027646,0.000370844,0.00005411492,0.002001131],"genre_scores_gemma":[0.9952425,0.0002983406,0.002371463,0.00003728558,0.000004903129,0.00002930243,0.0007045871,0.00001541524,0.001296327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542263,"threshold_uncertainty_score":0.005159378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03635277451592487,"score_gpt":0.297981080015262,"score_spread":0.2616283054993371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}