{"id":"W1512115582","doi":"10.4137/cmo.s612","title":"Disruption of the Non-Canonical WNT Pathway in Lung Squamous Cell Carcinoma","year":2008,"lang":"en","type":"article","venue":"Clinical medicine Oncology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"National Institute of Dental and Craniofacial Research; Genome British Columbia; Genome Canada","keywords":"Frizzled; Wnt signaling pathway; LRP5; Dishevelled; LRP6; Cancer research; WNT5A; Lung cancer; Beta-catenin; Medicine; Gene; Biology; Cancer; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462537,0.000165549,0.000192152,0.0006109046,0.0001693736,0.0002306956,0.000117563,0.0001875937,0.001042529],"category_scores_gemma":[0.0002523618,0.000151624,0.0001565053,0.0002648449,0.0002166044,0.0001733394,0.0001859515,0.0001898593,0.0003386638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245609,"about_ca_system_score_gemma":0.0003641814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008115933,"about_ca_topic_score_gemma":0.002601777,"domain_scores_codex":[0.9998243,0.0000225579,0.00001632524,0.00002640238,0.00007868528,0.00003176082],"domain_scores_gemma":[0.9998745,0.00002021333,0.00004134922,0.00001508996,0.00002206657,0.00002674484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001434656,0.00003201929,0.02855033,0.00007009608,0.00001521657,0.0007390631,0.00004496784,0.00006590352,0.9643565,0.0001072099,0.00005882648,0.005816498],"study_design_scores_gemma":[0.00001735674,0.000316598,0.4504061,0.00001618609,0.00005864559,0.005427168,0.0002532683,0.0009346324,0.5396177,0.0002289402,0.002713972,0.00000946917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955053,0.002662868,0.0008658907,0.00004587871,0.000006723662,0.00001622182,0.0001179247,0.00003176411,0.0007472475],"genre_scores_gemma":[0.9967362,0.001350034,0.0006279766,0.00002834087,0.00000414747,0.00001507403,0.0001995227,0.000006406022,0.001032332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042529,"threshold_uncertainty_score":0.003487587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373555541554224,"score_gpt":0.3430296636381071,"score_spread":0.3092941082225649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}