{"id":"W1512292489","doi":"","title":"Bioengineered Peptides Based on α1-PDX Structure as Inhibitors of Furin: Design, Synthesis and Comparative Efficacy","year":2006,"lang":"en","type":"article","venue":"Iranian journal of pharmaceutical sciences","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Furin; Serpin; Chemistry; Biochemistry; Amino acid; Peptide; Serine protease; Protease; Serine; Proteases; Enzyme; Proprotein convertase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987215,0.0001263845,0.0001868073,0.00006508613,0.00006750686,0.00003000713,0.0001662681,0.00007699109,0.00003697744],"category_scores_gemma":[0.0001025582,0.00008475105,0.00006835564,0.0001564162,0.0003395326,0.00001153171,0.00001973696,0.0001070521,5.262272e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007240398,"about_ca_system_score_gemma":0.00004898347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002491741,"about_ca_topic_score_gemma":4.666715e-7,"domain_scores_codex":[0.9990609,0.0000875111,0.0002878997,0.0001643213,0.0002464878,0.0001528943],"domain_scores_gemma":[0.9994922,0.00009450836,0.000163524,0.00005343007,0.00008766121,0.0001087375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000242333,0.00003617904,0.001017768,0.00001552053,0.00001315319,0.00000283958,0.0000164393,0.0007921554,0.9962109,0.00008371621,0.00007833766,0.001490669],"study_design_scores_gemma":[0.0004410328,0.0005120981,0.008436447,0.00004929852,0.0000266897,0.00003227223,0.00002210462,0.001146259,0.9886486,0.0001350504,0.000441938,0.0001082148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983233,0.0002949187,0.0005782072,0.0004879251,0.00009100007,0.00007837173,0.00001549212,0.000002791387,0.0001279489],"genre_scores_gemma":[0.9980029,0.00002381716,0.001654544,0.0001045764,0.0002007593,5.061884e-7,0.000002738059,0.000003719044,0.000006423536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007562294,"threshold_uncertainty_score":0.3456048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380847663008126,"score_gpt":0.3054663464904269,"score_spread":0.2673815801896143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}