{"id":"W1512292489","doi":"","title":"Bioengineered Peptides Based on α1-PDX Structure as Inhibitors of Furin: Design, Synthesis and Comparative Efficacy","year":2006,"lang":"en","type":"article","venue":"Iranian journal of pharmaceutical sciences","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Furin; Serpin; Chemistry; Biochemistry; Amino acid; Peptide; Serine protease; Protease; Serine; Proteases; Enzyme; Proprotein convertase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002162463,0.0003518467,0.0003164137,0.0002387904,0.00009791127,0.0003400539,0.0003075633,0.0003053754,0.0004074933],"category_scores_gemma":[0.0001652435,0.0001440202,0.0002458554,0.0001960383,0.0002073119,0.0003033703,0.0001490099,0.0004066656,0.0001521451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002708732,"about_ca_system_score_gemma":0.0001225884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001498524,"about_ca_topic_score_gemma":0.000169865,"domain_scores_codex":[0.9998889,0.00001860382,0.00001322743,0.0000257813,0.00003246036,0.00002110998],"domain_scores_gemma":[0.9999015,0.00001601306,0.00003694977,0.000005057976,0.00001303351,0.00002744455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003592726,0.0001507469,0.0001717348,0.0001886357,0.00001828115,0.0001529337,0.00003433785,0.001608281,0.9902963,0.0002286128,0.00003986144,0.006751066],"study_design_scores_gemma":[0.0001236643,0.003137188,0.001096042,0.00001576462,0.00004931036,0.000465968,0.00002359587,0.002122615,0.989009,0.00006271911,0.003880523,0.00001358181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852748,0.007677945,0.005342354,0.00006128851,0.0000357372,0.0001464106,0.0002142575,0.00003743063,0.001209818],"genre_scores_gemma":[0.9826019,0.005614234,0.01010417,0.00006576549,0.00002439208,0.00009396065,0.0003611587,0.00001326904,0.001121213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004074933,"threshold_uncertainty_score":0.001965344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380847663008126,"score_gpt":0.3054663464904269,"score_spread":0.2673815801896143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}