{"id":"W1512470862","doi":"10.1038/nchembio.1809","title":"Application guide for omics approaches to cell signaling","year":2015,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council","keywords":"Interactome; Computational biology; Omics; Biology; Proteomics; Signal transduction; Systems biology; Signaling proteins; Cell signaling; Bioinformatics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002387983,0.0001378231,0.000147457,0.00002305697,0.00002730067,0.00001120246,0.0002624245,0.0007773571,0.000001027262],"category_scores_gemma":[0.00009294254,0.0001214567,0.00007348818,0.00006276692,0.00004238516,0.000001576497,0.0001243644,0.0001838333,0.00001164461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002462935,"about_ca_system_score_gemma":0.00005574815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001735379,"about_ca_topic_score_gemma":0.000001319983,"domain_scores_codex":[0.9991664,0.00001199989,0.0002169771,0.0003057495,0.00004216863,0.0002567644],"domain_scores_gemma":[0.9994068,0.0000220097,0.00006977268,0.0002599899,0.00008059178,0.0001608639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149472,0.000028877,0.0001141098,0.0000149722,0.00001740016,5.529207e-8,0.00003239586,0.0001241872,0.9729593,0.001908113,0.01834704,0.006338621],"study_design_scores_gemma":[0.0004632,0.0001274518,0.000002918486,0.000001728661,0.00001063399,0.000003370056,0.00003611366,0.0008415561,0.6329035,0.00394519,0.3614836,0.0001807405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4455013,0.003359622,0.5381117,0.002160767,0.0006412747,0.001470439,0.0001795531,0.00005736308,0.008517883],"genre_scores_gemma":[0.958893,0.000008982125,0.0370845,0.001840958,0.0007536033,0.00009426286,0.001138494,0.0000180488,0.0001681204],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5133917,"threshold_uncertainty_score":0.599569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661151571016444,"score_gpt":0.2564059337969335,"score_spread":0.2297944180867691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}