{"id":"W1512812920","doi":"10.1074/jbc.m115.662155","title":"The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Enzyme; Ubiquitin-Protein Ligases; Prostate cancer; Cell biology; Chemistry; Biology; Cancer; Cancer research; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343912,0.0002706213,0.000299692,0.0002789209,0.000327505,0.0004720868,0.0002200887,0.0002321815,0.001713657],"category_scores_gemma":[0.0001214404,0.0001509145,0.0004186432,0.0004040612,0.0002241794,0.0001355126,0.0002758637,0.0005403908,0.0007137379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005943865,"about_ca_system_score_gemma":0.0003176547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002073121,"about_ca_topic_score_gemma":0.002223441,"domain_scores_codex":[0.9998149,0.00002078744,0.0000161858,0.00005101944,0.00005638388,0.00004069987],"domain_scores_gemma":[0.9999139,0.000006935265,0.00002715828,0.00001205521,0.00002039638,0.00001947969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001478161,0.00001623528,0.000744022,0.00005935052,0.00001732825,0.00005331646,0.00001661617,0.0001487045,0.9966814,0.000118086,0.0001893677,0.001807715],"study_design_scores_gemma":[0.00002208434,0.00009711865,0.02008567,0.000008262993,0.00004218426,0.0003493212,0.00005784885,0.002318157,0.9710432,0.0001111192,0.005850818,0.00001424396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770842,0.0105109,0.006115827,0.0003529157,0.0001262176,0.00003606103,0.002107266,0.0004634612,0.003203097],"genre_scores_gemma":[0.9941407,0.001223193,0.0009007649,0.0000692325,0.000008943894,0.00001595893,0.001238167,0.00002412998,0.002378959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002073121,"threshold_uncertainty_score":0.005732775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298506667074695,"score_gpt":0.2849213515329971,"score_spread":0.2550706848255276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}