{"id":"W1513277677","doi":"10.1002/cncr.28378","title":"Progression‐free survival: Does a correlation with survival justify its role as a surrogate clinical endpoint?","year":2013,"lang":"en","type":"letter","venue":"Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre","funders":"","keywords":"Surrogate endpoint; Medicine; Clinical endpoint; Progression-free survival; Endpoint Determination; Clinical trial; Overall survival; Survival analysis; Intensive care medicine; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01218923,0.001041546,0.002997656,0.0007818014,0.002714913,0.00406791,0.002714412,0.03072832,0.00246413],"category_scores_gemma":[0.07774622,0.0007233284,0.001692863,0.0009596605,0.003744095,0.004042433,0.00133382,0.05098718,0.003287744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003896636,"about_ca_system_score_gemma":0.004068946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002504659,"about_ca_topic_score_gemma":0.005299001,"domain_scores_codex":[0.9903663,0.003356472,0.001790843,0.000979928,0.002957069,0.0005493716],"domain_scores_gemma":[0.9518948,0.03509882,0.002336942,0.0007861666,0.007854861,0.002028521],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001337103,0.00002579167,0.0003678863,0.0001148859,0.00003417418,0.0006258906,0.00004230779,0.00006528669,0.0001070679,0.001965994,0.9828775,0.0136394],"study_design_scores_gemma":[0.0005438462,0.0002268641,0.001700131,0.0009707995,0.0001541357,0.002896606,0.0002524033,0.001073789,0.0006734402,0.01924712,0.9721203,0.0001405951],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000202799,0.003849339,0.0002510373,0.9173835,0.07736074,0.00001616527,0.0000503361,0.00001872537,0.0008674738],"genre_scores_gemma":[0.002166938,0.003133444,0.0004446545,0.8245916,0.1677791,0.00004725801,0.00002523217,0.00002290594,0.001788892],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9878108,"threshold_uncertainty_score":0.06446362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01994897843088424,"score_gpt":0.316233912221197,"score_spread":0.2962849337903128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}