{"id":"W1513465290","doi":"10.1523/jneurosci.22-21-09203.2002","title":"Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death","year":2002,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Heart and Stroke Foundation of Canada; National Institute of Neurological Disorders and Stroke; American Heart Association; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Barbiturate; NMDA receptor; Chemistry; Depolarization; Pharmacology; Neurotoxicity; Mitochondrion; Biophysics; Biochemistry; Biology; Receptor; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001750086,0.0006398363,0.0005711362,0.0002779944,0.0002252017,0.0002434351,0.0002408175,0.0003795016,0.001398748],"category_scores_gemma":[0.0002399189,0.0001642446,0.0004457932,0.0002813283,0.0003031381,0.0003073317,0.0003547769,0.0005125578,0.0004542505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004184531,"about_ca_system_score_gemma":0.0001998808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001811344,"about_ca_topic_score_gemma":0.005132835,"domain_scores_codex":[0.9997105,0.00005236976,0.00004168573,0.0000389731,0.00008934772,0.00006705972],"domain_scores_gemma":[0.9997557,0.00003330912,0.000112758,0.00003011169,0.00004229462,0.00002581855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001474747,0.00002376161,0.0003046586,0.0001337159,0.00002469405,0.0001880733,0.00003188774,0.00006064488,0.9969735,0.00009537122,0.00006411885,0.001952112],"study_design_scores_gemma":[0.00001246432,0.0006974416,0.01143029,0.00001968479,0.00005312162,0.0005924673,0.00003861769,0.0003188772,0.9841196,0.00005828857,0.002650751,0.000008285002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971983,0.01507605,0.006356948,0.0002938066,0.0001059815,0.0001224072,0.0005642949,0.0002401999,0.005257204],"genre_scores_gemma":[0.984728,0.008371967,0.003606644,0.0001660053,0.00007012723,0.00006011901,0.0004648241,0.00004057318,0.002491826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811344,"threshold_uncertainty_score":0.004679263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08239256410957013,"score_gpt":0.3221503141727686,"score_spread":0.2397577500631984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}