{"id":"W1513585608","doi":"10.1002/9780470514344.ch3","title":"Evolution of Secondary Metabolite Production: Potential Roles for Antibiotics as Prebiotic Effectors of Catalytic RNA Reactions","year":2007,"lang":"en","type":"review","venue":"Novartis Foundation symposium","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ribozyme; Intron; RNA; RNA splicing; Ligase ribozyme; Effector; Ribosomal RNA; Secondary metabolite; Prebiotic; Biology; Abiogenesis; Chemistry; Catalysis; Biochemistry; Genetics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007753802,0.0003602211,0.0008903375,0.0002963154,0.0001145219,0.00002657208,0.0002383677,0.0005191007,0.00002639367],"category_scores_gemma":[0.0002432435,0.0003452063,0.0005697684,0.0003216377,0.0001357104,0.00002084035,0.00006723775,0.0001366776,0.00001668873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007843928,"about_ca_system_score_gemma":0.0005629825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003234892,"about_ca_topic_score_gemma":0.00000908837,"domain_scores_codex":[0.9976726,0.000171229,0.001043477,0.0005776017,0.0002702316,0.0002649057],"domain_scores_gemma":[0.9976954,0.00005383118,0.001100305,0.0006458118,0.0004349675,0.00006968742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001142222,0.0001791344,0.000004496393,0.01224525,0.0005525367,6.903001e-7,0.00002396316,0.00004379922,0.6110128,0.001005031,0.00007208081,0.374746],"study_design_scores_gemma":[0.0002520475,0.0003631926,0.000008695391,0.001222728,0.001200794,0.00006606052,0.00001594032,0.000008618346,0.5431882,0.0001242263,0.4532305,0.0003190378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002221701,0.9502981,0.04104123,0.0000392194,0.002506825,0.00303712,0.0002295433,0.00003137425,0.0005949051],"genre_scores_gemma":[0.03783374,0.9532337,0.003570706,0.000009180932,0.001215258,0.00005105715,0.002320104,0.0001192096,0.001647],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4531584,"threshold_uncertainty_score":0.9999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126997413126194,"score_gpt":0.3096396276301453,"score_spread":0.2883696534988834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}