{"id":"W1514256570","doi":"10.1073/pnas.1505629112","title":"Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Prostate Cancer Foundation","keywords":"RNA interference; Gene silencing; Small interfering RNA; In vivo; Cancer; Cancer research; Biology; Chemistry; Transfection; RNA; Biochemistry; Gene; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004947594,0.00009109969,0.0001053446,0.0000440179,0.0001145382,0.00002147764,0.0003161818,0.00006449861,0.000001903542],"category_scores_gemma":[0.0001857999,0.00006184493,0.00007709383,0.0001709377,0.0001449115,0.00002071053,0.00007755103,0.00003528226,2.662401e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002871948,"about_ca_system_score_gemma":0.00009313935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001610047,"about_ca_topic_score_gemma":7.101719e-7,"domain_scores_codex":[0.999082,0.000004475427,0.0002332437,0.0002285902,0.0002952381,0.0001564342],"domain_scores_gemma":[0.9992541,0.00002010148,0.0002960916,0.000009195516,0.0003811059,0.00003938264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002039484,0.00003525093,0.02677578,0.00004679749,0.00001812943,3.451037e-9,0.0001924374,0.0006502442,0.9714963,0.00008137483,0.0003452557,0.0003380163],"study_design_scores_gemma":[0.0003139584,0.0001769614,0.005036399,0.00005959096,0.00002023785,0.000001868294,0.0002738029,0.003035192,0.9904459,0.0005099949,0.00004817622,0.00007799143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981178,0.0004719633,0.00001036009,0.0003044619,0.00002259155,0.0002863256,0.00001911904,0.000003502923,0.0007638713],"genre_scores_gemma":[0.9979642,0.00002611585,0.001500828,0.0001045175,0.0001369971,0.00005542742,0.000001008221,0.000005129821,0.0002057809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02173938,"threshold_uncertainty_score":0.2521963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05644654065827457,"score_gpt":0.3229097956002596,"score_spread":0.266463254941985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}