{"id":"W1514262699","doi":"10.1023/a:1020031023947","title":"Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFκB activation in epithelial derived cell lines","year":2002,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Manitoba Health Research Council","keywords":"FADD; Death domain; Caspase 8; HEK 293 cells; Cell biology; Programmed cell death; Apoptosis; Tumor necrosis factor alpha; Lactacystin; Receptor; Signal transduction; Biology; Caspase; Cancer research; Proteasome inhibitor; Proteasome; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004207838,0.0003613326,0.0002587415,0.0005683941,0.0003392415,0.0005854481,0.0002557071,0.0002724794,0.001645308],"category_scores_gemma":[0.0002266045,0.0002371016,0.0004830997,0.0005609072,0.0002305984,0.0003743705,0.0002560487,0.0008480982,0.0007078912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006680017,"about_ca_system_score_gemma":0.0004642263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00236938,"about_ca_topic_score_gemma":0.002697741,"domain_scores_codex":[0.9993999,0.0001104455,0.0001012925,0.00005175491,0.0001658259,0.0001708369],"domain_scores_gemma":[0.9997662,0.00004872447,0.00004579961,0.00005294487,0.00004776879,0.00003866082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004011914,0.0001437321,0.0008841759,0.0000915892,0.00001819084,0.0002118479,0.00008505279,0.0001418235,0.9957962,0.0004954378,0.0001570068,0.001573833],"study_design_scores_gemma":[0.00003607099,0.0003463771,0.00422508,0.000009527828,0.0000301431,0.0004200966,0.0001159423,0.0008052323,0.9909686,0.00005066669,0.0029866,0.000005615011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905149,0.002117669,0.003548288,0.0001388186,0.00004929025,0.00005262425,0.0009965526,0.00009348484,0.002488492],"genre_scores_gemma":[0.9902893,0.001344824,0.002255674,0.00005754592,0.000009881254,0.00004540234,0.001885785,0.0000110647,0.004100438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00236938,"threshold_uncertainty_score":0.005504072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235196121660728,"score_gpt":0.2144000865156911,"score_spread":0.2020481252990838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}