{"id":"W1514319231","doi":"10.3233/jad-131949","title":"Stimulation of Insulin Signaling and Inhibition of JNK-AP1 Activation Protect Cells from Amyloid-β-Induced Signaling Dysregulation and Inflammatory Response","year":2014,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Ottawa","funders":"National Research Council Canada; Canadian Institutes of Health Research; University of Ottawa","keywords":"AP-1 transcription factor; Insulin receptor; Insulin; Neuroinflammation; Signal transduction; Kinase; Cell biology; Chemistry; Biology; Cancer research; Transcription factor; Endocrinology; Immunology; Insulin resistance; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398952,0.0005241812,0.000457643,0.0002203413,0.0002335212,0.000361487,0.0002372757,0.0003036486,0.002179921],"category_scores_gemma":[0.00008663511,0.000145774,0.0004910743,0.0002845557,0.0001954992,0.0002395427,0.0002142989,0.001211752,0.0005378254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574571,"about_ca_system_score_gemma":0.0003078895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003518085,"about_ca_topic_score_gemma":0.0004860096,"domain_scores_codex":[0.999832,0.00001533011,0.00002553149,0.00003499322,0.00003846565,0.00005356121],"domain_scores_gemma":[0.9999347,0.000006892846,0.00001553558,0.000008837803,0.00001411632,0.0000200151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007312176,0.0001861544,0.0002236164,0.0002021317,0.00001541548,0.00006160474,0.00002845019,0.00005640045,0.9949707,0.00007000705,0.0001562543,0.003297927],"study_design_scores_gemma":[0.00009555102,0.00106355,0.007403707,0.00002112082,0.00004707065,0.0002993099,0.0000795929,0.0006135855,0.984977,0.00008998524,0.005298619,0.00001087752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794078,0.01010956,0.004327795,0.0003698901,0.0002906708,0.00009346953,0.001403601,0.0001691655,0.003828048],"genre_scores_gemma":[0.9794883,0.007142506,0.005311447,0.000320781,0.00006255699,0.000265846,0.002760245,0.00002386871,0.004624459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002179921,"threshold_uncertainty_score":0.007292569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0263772330444517,"score_gpt":0.2863245171006678,"score_spread":0.2599472840562161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}