{"id":"W1514929400","doi":"10.1002/ajh.23868","title":"A phase 2, randomized, double‐blind, placebo‐controlled study of siltuximab (anti‐IL‐6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma","year":2014,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"National Cancer Institute; Janssen Scientific Affairs; Leukemia and Lymphoma Society","keywords":"Medicine; Bortezomib; Internal medicine; Multiple myeloma; Gastroenterology; Neutropenia; Placebo; Dexamethasone; Refractory (planetary science); Discontinuation; Febrile neutropenia; Oncology; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002801666,0.002677911,0.003347108,0.0007622869,0.0005166397,0.001054426,0.001100852,0.00221697,0.004991469],"category_scores_gemma":[0.002082085,0.001394724,0.001717181,0.0005166666,0.001931624,0.001340457,0.0004560415,0.003389118,0.00107065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007160392,"about_ca_system_score_gemma":0.001259407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006575233,"about_ca_topic_score_gemma":0.001528091,"domain_scores_codex":[0.9990422,0.0005258237,0.00005932748,0.0002011936,0.00006603088,0.0001054409],"domain_scores_gemma":[0.9986375,0.0004003515,0.0003450275,0.000121841,0.00008074788,0.0004146158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9708428,0.01448083,0.0004018884,0.0003492366,0.000440731,0.00002979314,0.00005079422,0.0001967833,0.004255665,0.00007429736,0.0003460674,0.008531064],"study_design_scores_gemma":[0.9253831,0.07295081,0.0006272534,0.000009264191,0.0001585885,0.00001502329,0.000008933013,0.0002318019,0.0002920046,0.00006185696,0.0002539016,0.0000073623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872433,0.00319655,0.0009894472,0.0008044291,0.0008230546,0.004940353,0.0006808009,0.0001642847,0.001157888],"genre_scores_gemma":[0.9789062,0.002476458,0.002905991,0.001950317,0.00130151,0.007859102,0.0009736832,0.00004372013,0.003583143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004991469,"threshold_uncertainty_score":0.01669812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191206186390491,"score_gpt":0.3177636878295063,"score_spread":0.2986430691904571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}