{"id":"W1515929574","doi":"10.1038/labinvest.2009.111","title":"Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation","year":2009,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital; Western University","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Aggrecan; Chondrocyte; Chemistry; Cell biology; Protein kinase B; TGF alpha; PI3K/AKT/mTOR pathway; Kinase; Cartilage; Signal transduction; Growth factor; Cancer research; Medicine; Biology; Osteoarthritis; Pathology; Anatomy; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008795156,0.0001667913,0.0001774938,0.00009292897,0.0001344846,0.00004477442,0.00002626846,0.0001377905,0.00001557188],"category_scores_gemma":[0.00007256975,0.0001573178,0.00002648341,0.0002864566,0.000028355,0.0006613372,0.000003363589,0.0001150107,0.000009963841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007592236,"about_ca_system_score_gemma":0.00007982476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006833115,"about_ca_topic_score_gemma":0.000004952682,"domain_scores_codex":[0.9990676,0.0000491579,0.0002209381,0.0002424219,0.0002448414,0.0001750286],"domain_scores_gemma":[0.9994529,0.00002006036,0.00008951365,0.0001153803,0.0001453451,0.0001768323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002674534,0.00003679049,0.001491604,0.00002357032,0.000007590545,0.000003794938,0.0007286217,4.911596e-7,0.991621,0.001199956,0.0001379175,0.004721883],"study_design_scores_gemma":[0.001265421,0.0006557611,0.004877898,0.0001104563,0.00006836204,0.000004469767,0.0001972275,0.00003276427,0.9910349,0.001217599,0.0003866017,0.0001485159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969832,0.000253807,0.000615552,0.001356401,0.00005970788,0.0004595228,0.00002190997,0.0001217506,0.0001280954],"genre_scores_gemma":[0.9978162,0.00003704265,0.0005913129,0.001082163,0.00007014622,0.00002237899,0.0002909729,0.00001528087,0.00007451657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004573367,"threshold_uncertainty_score":0.6415233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320961769159841,"score_gpt":0.22934640614018,"score_spread":0.2161367884485816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}