{"id":"W1516646538","doi":"10.1038/nchembio.1867","title":"The promise and peril of chemical probes","year":2015,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":850,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Simon Fraser University; Structural Genomics Consortium; Princess Margaret Cancer Centre","funders":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill; National Institute of General Medical Sciences; Medical Research Council; Novartis Institutes for BioMedical Research; University of North Carolina at Chapel Hill; Janssen Research and Development; National Institutes of Health; University of Toronto; Harvard University; Österreichischen Akademie der Wissenschaften; Monash University; Cancer Research UK; National Center for Advancing Translational Sciences; Wellcome Trust; GlaxoSmithKline; Constellation Pharmaceuticals; Eli Lilly and Company; University of Dundee; University of Oxford; Pfizer","keywords":"Quality (philosophy); Computer science; Data science; Resource (disambiguation); Risk analysis (engineering); Business; Epistemology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02804844,0.001078899,0.0009776107,0.002448606,0.002563085,0.01031308,0.003097337,0.008119388,0.01579986],"category_scores_gemma":[0.04768088,0.0007135879,0.0009158943,0.001775143,0.007644267,0.03386348,0.006737324,0.01277172,0.006843123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002453527,"about_ca_system_score_gemma":0.003671446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008458304,"about_ca_topic_score_gemma":0.0009498495,"domain_scores_codex":[0.9870368,0.004724394,0.0004786688,0.0009967729,0.006205832,0.000557459],"domain_scores_gemma":[0.9514719,0.02946743,0.001658552,0.005284009,0.006509816,0.005608364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002784833,0.0001523704,0.0008456186,0.001814967,0.00007241439,0.0003846656,0.0008107033,0.001024751,0.01074967,0.4828773,0.1867631,0.314226],"study_design_scores_gemma":[0.0000207251,0.00008154164,0.0001873857,0.0003320757,0.00001751084,0.0002804798,0.0003372715,0.0008093223,0.005083712,0.1326917,0.8601155,0.00004282664],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01045219,0.2033983,0.1168408,0.5289795,0.03277991,0.0001439388,0.001468942,0.005474475,0.100462],"genre_scores_gemma":[0.2178064,0.2931119,0.1915341,0.1642271,0.02462478,0.0009162977,0.003132822,0.003440838,0.1012058],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02804844,"threshold_uncertainty_score":0.1483361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197405333482197,"score_gpt":0.2792166934164036,"score_spread":0.2672426400815816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}