{"id":"W1516873381","doi":"10.4049/jimmunol.181.4.2285","title":"CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Moffitt Cancer Center","keywords":"CD28; FOXP3; IL-2 receptor; Biology; Homeostasis; T cell; Cell biology; Cellular differentiation; Immunology; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241207,0.0003105631,0.0002113456,0.0001560682,0.000119281,0.0003345378,0.0002020994,0.000169773,0.0009311886],"category_scores_gemma":[0.0001878189,0.0001193948,0.0001107242,0.00008110201,0.0001992346,0.000173996,0.0002672055,0.0005081166,0.0004463511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419134,"about_ca_system_score_gemma":0.0002438089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003757153,"about_ca_topic_score_gemma":0.0007500912,"domain_scores_codex":[0.9997159,0.00005181997,0.00001811685,0.00007037166,0.00005813282,0.0000856176],"domain_scores_gemma":[0.9998417,0.00002229797,0.00003139987,0.00001453793,0.00001915005,0.00007086078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008411577,0.00001291698,0.0001405915,0.00001339014,9.539013e-7,0.00004201209,0.000007026135,0.00003379257,0.9989188,0.00004066417,0.00001856472,0.0006872093],"study_design_scores_gemma":[0.00005068399,0.0002968759,0.005654111,0.000006773576,0.000009572309,0.0002964747,0.00003387544,0.001461904,0.9893774,0.0001108816,0.002697294,0.000004074455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930823,0.001883876,0.002472209,0.00005732486,0.00003743539,0.00001859838,0.0001345848,0.00009627962,0.002217397],"genre_scores_gemma":[0.9968363,0.0004388703,0.001237369,0.00002979307,0.00001688872,0.00001522447,0.0001783184,0.00002933878,0.001217943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009311886,"threshold_uncertainty_score":0.003115177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009496739487691008,"score_gpt":0.1960746386569487,"score_spread":0.1865778991692577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}