{"id":"W1516873381","doi":"10.4049/jimmunol.181.4.2285","title":"CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Moffitt Cancer Center","keywords":"CD28; FOXP3; IL-2 receptor; Biology; Homeostasis; T cell; Cell biology; Cellular differentiation; Immunology; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000510002,0.0002987933,0.000928377,0.0002417727,0.0002849979,0.000004991996,0.0009030467,0.0005467914,0.0009776974],"category_scores_gemma":[0.00006846683,0.0002001199,0.0003233408,0.0001481798,0.001377113,0.0001354254,0.0001713301,0.0009570027,0.0003519343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006675214,"about_ca_system_score_gemma":0.0001669364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093532,"about_ca_topic_score_gemma":0.000008765418,"domain_scores_codex":[0.9969196,0.001157722,0.001169734,0.0001927309,0.00009265887,0.0004674998],"domain_scores_gemma":[0.9965286,0.0009133817,0.001584029,0.0006001217,0.0003492816,0.00002462234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001540054,0.0003252156,0.0004462576,0.000005726607,0.001389036,0.00001944144,0.00154923,0.00002726474,0.9904008,0.0001790044,0.003180497,0.0009374552],"study_design_scores_gemma":[0.00409611,0.000930607,0.01036431,0.00004006309,0.0002838143,0.0006376862,0.0005903547,0.000002735639,0.9752628,0.0005449858,0.007058914,0.000187631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746014,0.02085696,0.0003886064,0.000315815,0.003311969,0.0001909424,0.00003771225,0.00002308165,0.0002734592],"genre_scores_gemma":[0.9946346,0.003345806,0.00007570398,0.0001610266,0.000101695,0.000002862233,0.00002034519,0.00002700648,0.001630932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02003317,"threshold_uncertainty_score":0.9999356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009496739487691008,"score_gpt":0.1960746386569487,"score_spread":0.1865778991692577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}