{"id":"W1517016448","doi":"10.1111/j.1471-4159.2011.07466.x","title":"α7 Nicotinic receptor activation reduces β‐amyloid‐induced apoptosis by inhibiting caspase‐independent death through phosphatidylinositol 3‐kinase signaling","year":2011,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Neuroprotection; Methyllycaconitine; Neurotoxicity; Nicotine; Protein kinase B; PI3K/AKT/mTOR pathway; Phosphatidylinositol; Pharmacology; Programmed cell death; Caspase; Cell biology; Chemistry; Signal transduction; Biology; Apoptosis; Nicotinic agonist; Nicotinic acetylcholine receptor; Biochemistry; Receptor; Neuroscience; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004064707,0.0004175249,0.000446017,0.00004839067,0.0001813966,0.0000584204,0.0005737218,0.0003534288,0.0001320188],"category_scores_gemma":[0.0005887027,0.0004073968,0.0003354115,0.0001814238,0.00005865581,0.00005314371,0.0001990668,0.0006730025,0.000008618074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008450787,"about_ca_system_score_gemma":0.0002586843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000023046,"about_ca_topic_score_gemma":4.613408e-7,"domain_scores_codex":[0.9972642,0.0001308444,0.001050678,0.0005490835,0.0005297398,0.0004754677],"domain_scores_gemma":[0.9975548,0.00006196861,0.0013655,0.0003471386,0.0004333784,0.0002371857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002624806,0.0004372566,0.0008305924,0.00003399313,0.0001485535,0.000002478383,0.0002809836,0.00000913913,0.9923127,0.000002126377,0.005122161,0.0005575895],"study_design_scores_gemma":[0.001227311,0.000551828,0.00009805449,0.0001428676,0.000086101,0.00009753476,0.0007412683,0.000003676787,0.9955432,0.00001411712,0.001112977,0.0003810166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971915,0.0003512324,0.000394244,0.000150885,0.0004495756,0.0001870612,0.00001635205,0.00002118005,0.001237931],"genre_scores_gemma":[0.9961963,0.0002729,0.001837009,0.0002534848,0.001024235,0.00001144938,0.00004962807,0.00007644939,0.0002784898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004009184,"threshold_uncertainty_score":0.9998378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074597345177527,"score_gpt":0.2667930962805244,"score_spread":0.2360471228287492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}