{"id":"W1517105897","doi":"10.1186/ar1427","title":"Regulation of T-cell differentiation by IL-4Rα-chain single nucleotide polymorphisms","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Biology; Immunology; T cell; Single-nucleotide polymorphism; Interleukin-7 receptor; IL-2 receptor; Immune system; Allele; CD28; BCL6; Molecular biology; Genetics; Genotype; B cell; Antibody; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004954247,0.0001644126,0.0002900408,0.0002807558,0.0003253137,0.00002441804,0.0002901331,0.0003272829,0.001006822],"category_scores_gemma":[0.00008055104,0.0001660663,0.00009531254,0.0003292283,0.0006439977,0.0001430709,0.0001555091,0.0004854479,0.001061653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001004934,"about_ca_system_score_gemma":0.00007887938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008277767,"about_ca_topic_score_gemma":0.0001717955,"domain_scores_codex":[0.9979548,0.0004357678,0.0004258994,0.0003896332,0.0001472297,0.0006467098],"domain_scores_gemma":[0.999041,0.0001748721,0.0001214828,0.0004092416,0.0002166215,0.00003679849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001063656,0.0006773576,0.0003180903,0.00001287268,0.00003674393,0.000004405862,0.000342528,0.000005097675,0.982204,0.001487562,0.003667575,0.01113737],"study_design_scores_gemma":[0.002856113,0.0007010818,0.001420367,0.00006718942,0.000005755322,0.00002415785,0.0001854196,0.00000217809,0.9779192,0.003046784,0.0136135,0.0001582741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874387,0.007408335,0.0002904494,0.0007035976,0.0004310438,0.0003222671,0.00006335776,0.00006458127,0.003277664],"genre_scores_gemma":[0.9925888,0.0008795966,0.0000892469,0.00003323597,0.00003872987,0.00002473979,0.0003412084,0.00002842153,0.005975995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01097909,"threshold_uncertainty_score":0.9999064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02103278999637795,"score_gpt":0.2537932246107803,"score_spread":0.2327604346144024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}