{"id":"W1517758150","doi":"10.4049/jimmunol.164.1.136","title":"A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases","keywords":"Experimental autoimmune encephalomyelitis; CD28; Immunology; Nod; T cell; Immune system; Biology; NOD mice; Antigen; Autoimmunity; Medicine; In vivo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007202381,0.0003151934,0.0007539134,0.0002641769,0.000397408,0.00002509326,0.0004215961,0.0002811239,0.0003335836],"category_scores_gemma":[0.00008585574,0.000245266,0.0001246502,0.0001849779,0.0009220768,0.000198298,0.000120909,0.0008012856,0.00003325413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409613,"about_ca_system_score_gemma":0.000117029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002706765,"about_ca_topic_score_gemma":0.00001146409,"domain_scores_codex":[0.9970753,0.001038997,0.0009610511,0.0002806146,0.00007815407,0.0005659373],"domain_scores_gemma":[0.9982333,0.0009492969,0.0003233666,0.0002606438,0.0002052502,0.00002811887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003836669,0.001400804,0.0008251463,0.000005558367,0.0003724181,0.00002331878,0.007664506,0.001044345,0.9836094,0.0001362544,0.00001338239,0.00106819],"study_design_scores_gemma":[0.03677775,0.01688835,0.0714483,0.0003282528,0.0009858855,0.008634417,0.06162781,0.008311971,0.7900801,0.0009789772,0.002608914,0.001329242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958815,0.03948972,0.0002643548,0.0001732246,0.0004658248,0.0006779014,0.0000136855,0.00001942256,0.00008088218],"genre_scores_gemma":[0.9994085,0.0001427942,0.0001940716,0.00007540928,0.00003587338,0.00001721722,0.00001394721,0.00002243567,0.0000896852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1935293,"threshold_uncertainty_score":0.9999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022582407893877,"score_gpt":0.3161625951509406,"score_spread":0.2935801872570636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}