{"id":"W1518556167","doi":"10.1371/journal.ppat.1004887","title":"The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Entamoeba histolytica; Inflammasome; Integrin; Cell biology; Biology; Integrin alpha M; Extracellular; Microbiology; Receptor; Immunology; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003137426,0.0004598491,0.0003515646,0.000270498,0.0003784858,0.0004905685,0.0002030946,0.000821425,0.001661552],"category_scores_gemma":[0.0002607554,0.0001774899,0.0007071513,0.0001953976,0.0002867726,0.0006539979,0.0005720718,0.0007728895,0.0005398083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003375128,"about_ca_system_score_gemma":0.0002267275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001845946,"about_ca_topic_score_gemma":0.000214909,"domain_scores_codex":[0.9995213,0.0001008699,0.0000740159,0.00009887528,0.0001231618,0.00008185831],"domain_scores_gemma":[0.9998572,0.000009916962,0.00006190493,0.00001110454,0.0000298346,0.00003013641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002148063,0.00002933016,0.0006800146,0.0002349235,0.00001792739,0.0006815504,0.0000907401,0.00006309924,0.9955651,0.000284631,0.0001930071,0.001944837],"study_design_scores_gemma":[0.0001419088,0.0009894124,0.0479445,0.000131819,0.0001153847,0.007701497,0.0006400823,0.004184297,0.9163722,0.001595847,0.02013421,0.00004885584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9394386,0.03209184,0.01852058,0.00153131,0.0004299399,0.0002034816,0.001154852,0.0003494797,0.00627993],"genre_scores_gemma":[0.9876286,0.003407391,0.004501875,0.0003819913,0.00005499581,0.00007255778,0.0007799324,0.00001734968,0.003155452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001661552,"threshold_uncertainty_score":0.005558431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03495448209096527,"score_gpt":0.2574246735778588,"score_spread":0.2224701914868935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}