{"id":"W1519070625","doi":"10.1016/s0076-6879(05)00033-9","title":"Pregnane X Receptor‐Mediated Transcription","year":2005,"lang":"en","type":"article","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences","keywords":"Pregnane X receptor; Nuclear receptor; Transcription factor; Xenobiotic; Cell biology; Drug metabolism; Constitutive androstane receptor; Gastrointestinal tract; Biology; Pregnane; Receptor; Reporter gene; Transcription (linguistics); Endogeny; Chemistry; Biochemistry; Pharmacology; Gene expression; Gene; Drug; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.01885686,0.001196899,0.002226814,0.00200415,0.0002990515,0.00003081926,0.001511994,0.003146428,0.006099612],"category_scores_gemma":[0.003046736,0.001252443,0.0004331516,0.001796027,0.001317562,0.0002580953,0.0003255166,0.005330388,0.0006026502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000547062,"about_ca_system_score_gemma":0.0002657679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001077445,"about_ca_topic_score_gemma":0.0004488192,"domain_scores_codex":[0.9591371,0.03346276,0.002480004,0.002047179,0.0003577615,0.002515213],"domain_scores_gemma":[0.9876398,0.009807468,0.0006460102,0.001071926,0.0001932155,0.0006415903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001353907,0.001857237,0.004495563,0.00006075014,0.0001978033,0.0001951359,0.002003993,0.003530873,0.6717065,0.004749699,0.002053173,0.3077954],"study_design_scores_gemma":[0.0106952,0.0009031713,0.03723884,0.00007670861,0.0002467053,0.0003785355,0.0002493942,0.003560108,0.2522081,0.01188504,0.6808888,0.001669389],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8814851,0.01847881,0.04400378,0.006956617,0.01941774,0.002993472,0.0002218805,0.0006625024,0.02578007],"genre_scores_gemma":[0.1824523,0.004121243,0.7968249,0.01217033,0.001168432,0.0008387135,0.0001252577,0.0002113961,0.002087472],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7528211,"threshold_uncertainty_score":0.9989926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1697954661555574,"score_gpt":0.5290633822734421,"score_spread":0.3592679161178847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}