{"id":"W1519329230","doi":"10.1111/tra.12003","title":"Rab7 and Arl8 <scp>GTPases</scp> are Necessary for Lysosome Tubulation in Macrophages","year":2012,"lang":"en","type":"article","venue":"Traffic","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Toronto Metropolitan University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Cell biology; Lysosome; Biology; Endosome; Phagosome; Endocytic cycle; Rab; Microtubule; Motor protein; Dynein; GTPase; Endocytosis; Phagocytosis; Biochemistry; Cell; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382696,0.0001075216,0.0001092055,0.00004350233,0.00004270129,0.00001249003,0.0000488585,0.0001324206,0.000005608765],"category_scores_gemma":[0.00002297433,0.0001082077,0.00004978711,0.00005459736,0.00003034039,0.000008396156,0.000009848115,0.00004937546,0.000003419637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006520258,"about_ca_system_score_gemma":0.00001076625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003331058,"about_ca_topic_score_gemma":0.00003985238,"domain_scores_codex":[0.999382,0.00001999198,0.0001361337,0.0001796817,0.0000587496,0.000223408],"domain_scores_gemma":[0.9997351,0.00001866101,0.00004535065,0.0001145225,0.00001992695,0.00006643844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001024261,0.0002190971,0.09822048,0.0001780237,0.00003795361,0.00000540691,0.0007038648,0.0009110359,0.8942697,0.00007632475,0.0004889166,0.004786799],"study_design_scores_gemma":[0.003550384,0.0003882798,0.682057,0.00006466028,0.00009861389,0.00003110156,0.0006936222,0.002312375,0.209667,0.00008446635,0.1007141,0.0003383421],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938541,0.004091614,0.001573102,0.00004639446,0.0001077797,0.0002146857,0.00001886817,0.00001417659,0.00007929146],"genre_scores_gemma":[0.997539,0.0002217525,0.0001795173,0.000062307,0.0002350543,0.00002462335,0.001426452,0.00001776413,0.0002935051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6846027,"threshold_uncertainty_score":0.4412582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148445085831745,"score_gpt":0.2327686260393118,"score_spread":0.2212841751809943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}