{"id":"W1519477212","doi":"10.3233/jad-2011-101791","title":"Implication of a Genetic Variant at PICALM in Alzheimer's Disease Patients and Centenarians","year":2011,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AGE-WELL","keywords":"Genotype; Genome-wide association study; Allele; Biology; Genetics; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003521335,0.0006761756,0.0006627947,0.001981522,0.000855101,0.00083832,0.0003481036,0.0007199997,0.003564761],"category_scores_gemma":[0.002062763,0.0002859481,0.00038035,0.001224537,0.0007014157,0.0002331201,0.0005484897,0.0003790259,0.0003461854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912173,"about_ca_system_score_gemma":0.0001419267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003301848,"about_ca_topic_score_gemma":0.001929432,"domain_scores_codex":[0.9997434,0.00004330096,0.00004107855,0.00008792867,0.00003610379,0.00004810215],"domain_scores_gemma":[0.9992558,0.0001684142,0.0002869928,0.0001131766,0.0000532477,0.000122377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005131981,0.0001312115,0.9458308,0.0001143497,0.0003478595,0.007798699,0.00211374,0.0001254591,0.02722111,0.0003037855,0.0003024805,0.01057853],"study_design_scores_gemma":[0.00005618763,0.0002263217,0.9921119,0.00001914008,0.0001555902,0.005201252,0.0004752674,0.0001515238,0.0008853607,0.0001715126,0.000524706,0.00002104187],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994677,0.0001347073,0.00004526939,0.00001690855,0.000004948135,0.000002824902,0.00006351875,0.000003270537,0.0002608527],"genre_scores_gemma":[0.9996278,0.00006146821,0.0000500945,0.0000125449,0.000007954202,0.000003683038,0.00007049268,0.000002671545,0.0001632049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003564761,"threshold_uncertainty_score":0.01192534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607691510832245,"score_gpt":0.2248692204716103,"score_spread":0.2087923053632879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}