{"id":"W1519704494","doi":"10.1016/j.jmb.2008.07.057","title":"Crystal Structure of the Complex between the Fab′ Fragment of the Cross-Neutralizing Anti-HIV-1 Antibody 2F5 and the Fab Fragment of Its Anti-idiotypic Antibody 3H6","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Sanofi Pasteur; University of Toronto; Fonds Québécois de la Recherche sur la Nature et les Technologies; Canada Research Chairs","keywords":"Paratope; Epitope; Gp41; Monoclonal antibody; Antibody; Idiotype; Molecular biology; Linear epitope; Chemistry; Antigen; Virology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004046383,0.0007252988,0.001279382,0.0002838162,0.0009912711,0.001460856,0.001727346,0.00103431,0.005323146],"category_scores_gemma":[0.0007613454,0.0005013064,0.0003298048,0.0005237824,0.0004005714,0.000645888,0.0003851059,0.002921595,0.0007934765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002536737,"about_ca_system_score_gemma":0.002055719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02561662,"about_ca_topic_score_gemma":0.021977,"domain_scores_codex":[0.9997701,0.00002431782,0.000007487477,0.00004661113,0.00007796053,0.00007346574],"domain_scores_gemma":[0.9997658,0.00009188015,0.00003439741,0.000008762822,0.00003801572,0.00006107471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01257346,0.004764304,0.03985859,0.004899734,0.002286766,0.01526086,0.005706682,0.03298687,0.5330586,0.04949866,0.2051762,0.09392923],"study_design_scores_gemma":[0.00740379,0.002989991,0.1880469,0.00106913,0.001793121,0.01224558,0.005566307,0.1906057,0.2836039,0.008996973,0.2968407,0.0008378479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559505,0.01416606,0.002628707,0.003258266,0.000799927,0.0001090118,0.006551199,0.000661179,0.01587523],"genre_scores_gemma":[0.9530356,0.008368867,0.005709382,0.001485031,0.000117101,0.00009041928,0.02024478,0.0001249887,0.01082385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02561662,"threshold_uncertainty_score":0.05093503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660053785406418,"score_gpt":0.3079531107950357,"score_spread":0.2913525729409715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}