{"id":"W1519870808","doi":"10.1002/9781118705308.ch9","title":"Multidrug Resistance Protein","year":2014,"lang":"en","type":"other","venue":"","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Multiple drug resistance; P-glycoprotein; Pharmacokinetics; ATP-binding cassette transporter; Flippase; Drug resistance; Liposome; Lipid bilayer; Cell; Vesicle; Drug; Pharmacology; Chemistry; Biology; Cell biology; Cancer research; Transporter; Biochemistry; Membrane; Gene; Genetics; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001918635,0.0002879249,0.0002678268,0.000707225,0.0004501819,0.0009064768,0.0002201428,0.0003958708,0.01003672],"category_scores_gemma":[0.0003182255,0.00007014281,0.0002562589,0.0007717181,0.0003339473,0.000342749,0.0005408326,0.0004602581,0.00435595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006107754,"about_ca_system_score_gemma":0.0004129061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005324754,"about_ca_topic_score_gemma":0.0005524039,"domain_scores_codex":[0.9998423,0.00002245794,0.00001232327,0.00003576038,0.00005995144,0.00002724838],"domain_scores_gemma":[0.9998758,0.000008942315,0.00003083894,0.00001314311,0.0000371912,0.00003403457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005733464,0.0003032761,0.01470227,0.001117333,0.0001472793,0.003612933,0.0002956419,0.0003792821,0.4113638,0.04765864,0.0567236,0.4631226],"study_design_scores_gemma":[0.00003428122,0.0002087876,0.020772,0.00008070202,0.00005156473,0.009082763,0.00009317135,0.0004276602,0.08063971,0.002905519,0.8856828,0.00002110181],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.43223,0.1472318,0.02795863,0.01101049,0.00169312,0.0005926315,0.01460382,0.002041511,0.3626381],"genre_scores_gemma":[0.6998093,0.03684767,0.008814016,0.001851006,0.0002517453,0.0001992381,0.010424,0.0001056403,0.2416973],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01003672,"threshold_uncertainty_score":0.03357625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005962708137889364,"score_gpt":0.2246304762297036,"score_spread":0.2186677680918142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}