{"id":"W1520464148","doi":"10.1038/nrcardio.2015.64","title":"Genotype-based clinical trials in cardiovascular disease","year":2015,"lang":"en","type":"review","venue":"Nature Reviews Cardiology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Heart Research Centre","funders":"National Institute of General Medical Sciences","keywords":"Pharmacogenomics; Clinical trial; Medicine; Randomized controlled trial; Intensive care medicine; Adverse effect; Pharmacogenetics; Population; Drug development; Disease; Psychological intervention; Clinical study design; Drug; Pharmacology; Internal medicine; Psychiatry; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch","metaepi_narrow","metaepi_broad","research_integrity"],"category_scores_codex":[0.09268802,0.00143409,0.02327401,0.0006791282,0.0001121177,0.0000293784,0.001480199,0.006429088,0.0003188805],"category_scores_gemma":[0.0149505,0.001041108,0.01318192,0.001005926,0.0004389267,0.00005601781,0.0003320043,0.01046372,0.001396856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002864226,"about_ca_system_score_gemma":0.002742977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003476791,"about_ca_topic_score_gemma":0.000001823205,"domain_scores_codex":[0.9095898,0.08160779,0.005493607,0.001732479,0.0004674941,0.001108809],"domain_scores_gemma":[0.9893489,0.005254516,0.001754712,0.001940531,0.0002765296,0.001424752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001285515,0.0001239537,0.0000994638,0.007136669,0.00298865,0.0005175815,0.000005731253,0.000215356,3.30306e-7,0.0001774977,0.03365183,0.9549544],"study_design_scores_gemma":[0.002067195,0.00004248688,0.00001896005,0.001538466,0.02413729,0.00006222462,0.00000109619,0.00005162838,4.092563e-7,0.0001942664,0.9709399,0.0009460711],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003392276,0.977253,0.00009099028,0.00008842013,0.01259683,0.005986087,0.0007207736,0.00008733135,0.003173168],"genre_scores_gemma":[0.00001581463,0.9881629,0.0002395039,0.002274286,0.006703605,0.001402861,0.0008511118,0.0001603679,0.000189553],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9540083,"threshold_uncertainty_score":0.9998409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5735216600164936,"score_gpt":0.6214075842620781,"score_spread":0.04788592424558447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}