{"id":"W1520480153","doi":"10.1186/ar1788","title":"The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases","year":2005,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Cathepsin K; Osteoarthritis; Aggrecanase; Cartilage; ADAMTS; Medicine; Cathepsin; Internal medicine; Pharmacology; Pathology; Matrix metalloproteinase; Chemistry; Anatomy; Metalloproteinase; Biochemistry; Osteoclast; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006483311,0.0002515412,0.0004961909,0.0001585718,0.0003478822,0.00003093658,0.0001121118,0.0001139736,0.00004070524],"category_scores_gemma":[0.000099443,0.0001348185,0.00008050777,0.000261247,0.0007595217,0.0001457455,0.00004735993,0.0002439023,0.000001549596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004851997,"about_ca_system_score_gemma":0.00008201055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004484695,"about_ca_topic_score_gemma":0.0003848309,"domain_scores_codex":[0.9976023,0.000613667,0.000327933,0.0003476441,0.0007426231,0.0003658756],"domain_scores_gemma":[0.9984102,0.0006287,0.0001896631,0.0004251102,0.0002228771,0.0001234672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00465713,0.000202225,0.0005378892,0.00002904497,0.000051716,0.00001075944,0.0040857,0.000001258459,0.818385,0.00002709395,0.00002615929,0.171986],"study_design_scores_gemma":[0.006785083,0.01620804,0.002826033,0.00127679,0.0000185634,0.00004363565,0.00116536,0.00001429879,0.9713542,0.00001929768,0.0001732586,0.0001154536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783354,0.01720911,0.000004186109,0.0004106963,0.00001270537,0.003846669,0.00009280378,0.00001795017,0.00007050943],"genre_scores_gemma":[0.9972839,0.001662287,0.0001390925,0.00001386797,0.00004642646,0.0006733423,0.00001563253,0.00003824289,0.0001271449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1718705,"threshold_uncertainty_score":0.549774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586105131825706,"score_gpt":0.2856942830907537,"score_spread":0.2698332317724966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}