{"id":"W1520953238","doi":"10.1016/j.clim.2008.12.008","title":"IL-1β and IL-2 convert human Treg into TH17 cells","year":2009,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":176,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Ludwig Institute for Cancer Research; Conseil Régional des Pays de la Loire; Cancer Research Institute","keywords":"FOXP3; Autoimmunity; IL-2 receptor; Immunology; Inflammation; Interleukin 17; RAR-related orphan receptor gamma; Cell biology; Interleukin 12; Biology; T cell; Immune system; Cytotoxic T cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004711122,0.0005952201,0.0003574414,0.0003784419,0.0001495381,0.0006739775,0.0002129604,0.0003760681,0.003834457],"category_scores_gemma":[0.0003954594,0.000269351,0.0005096199,0.000140941,0.0002035612,0.0002875016,0.0002735638,0.001667447,0.001657658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001488213,"about_ca_system_score_gemma":0.0003013412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003062892,"about_ca_topic_score_gemma":0.0004017375,"domain_scores_codex":[0.9995968,0.00008991759,0.00003107131,0.00004963533,0.00006499414,0.0001676839],"domain_scores_gemma":[0.9998037,0.00005333368,0.00002822158,0.00005004272,0.00001792351,0.00004676061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00178243,0.0004461709,0.0013046,0.0001167129,0.0000299136,0.0004245428,0.00008604897,0.000258787,0.9772674,0.0003334224,0.0007147961,0.01723512],"study_design_scores_gemma":[0.001465963,0.00545572,0.01392371,0.0000943787,0.0001380432,0.002506003,0.0002319542,0.001349619,0.9482965,0.001106393,0.02540385,0.00002781888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823065,0.006931442,0.004113091,0.0003049401,0.0005207162,0.0002183686,0.0006207204,0.0001481499,0.004835941],"genre_scores_gemma":[0.9902598,0.002422648,0.001471111,0.0003135179,0.0002888965,0.0001421084,0.0007437101,0.00004873966,0.004309521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003834457,"threshold_uncertainty_score":0.01282752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02717478298656901,"score_gpt":0.3095264878523234,"score_spread":0.2823517048657544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}