{"id":"W1520953238","doi":"10.1016/j.clim.2008.12.008","title":"IL-1β and IL-2 convert human Treg into TH17 cells","year":2009,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":176,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Ludwig Institute for Cancer Research; Conseil Régional des Pays de la Loire; Cancer Research Institute","keywords":"FOXP3; Autoimmunity; IL-2 receptor; Immunology; Inflammation; Interleukin 17; RAR-related orphan receptor gamma; Cell biology; Interleukin 12; Biology; T cell; Immune system; Cytotoxic T cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0007183758,0.0005259599,0.001243918,0.0002086414,0.0005798448,0.00003387235,0.0007885683,0.001804032,0.001310555],"category_scores_gemma":[0.000229182,0.0004657788,0.0003488082,0.000192836,0.002764975,0.000149853,0.0003821327,0.001666497,0.003529145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004867388,"about_ca_system_score_gemma":0.00009775809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001365869,"about_ca_topic_score_gemma":0.00004150157,"domain_scores_codex":[0.9955418,0.0009540513,0.001395492,0.001053617,0.00004689559,0.001008139],"domain_scores_gemma":[0.997583,0.0007835833,0.0004026323,0.001017172,0.0001342797,0.00007933174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003706275,0.0007712949,0.001104268,0.000008091417,0.0005128739,0.00004356948,0.0002736657,2.726557e-7,0.9198801,0.00414858,0.009099185,0.0637875],"study_design_scores_gemma":[0.01046733,0.007087647,0.02388838,0.00006133933,0.000349627,0.0004089223,0.0005062802,0.000009728023,0.3635085,0.01481099,0.5777002,0.001201076],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765728,0.01179972,0.0000933762,0.00294465,0.003830111,0.0004004698,0.00003207437,0.0003345545,0.003992233],"genre_scores_gemma":[0.9816708,0.002684097,0.000293723,0.00261874,0.0001633788,0.0000199871,0.0001681197,0.00003900705,0.01234213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.568601,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02717478298656901,"score_gpt":0.3095264878523234,"score_spread":0.2823517048657544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}