{"id":"W1521289261","doi":"10.1007/10_2013_223","title":"Exploration of Structure-Switching in the Design of Aptamer Biosensors","year":2013,"lang":"en","type":"article","venue":"Advances in biochemical engineering, biotechnology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Aptamer; Biosensor; Nanotechnology; Biomolecule; Function (biology); Computer science; Materials science; Biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433336,0.0001685118,0.00024469,0.0002166524,0.00001000804,0.000003864831,0.0003111231,0.0003728033,0.000001427223],"category_scores_gemma":[0.0002653741,0.0001256276,0.00005386358,0.000469377,0.0001613093,0.00002052707,0.00006762284,0.0002172363,3.747288e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001359157,"about_ca_system_score_gemma":0.00001057911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001981307,"about_ca_topic_score_gemma":0.000007947609,"domain_scores_codex":[0.9989673,0.00003588535,0.0003959149,0.0002797135,0.0001049858,0.0002161278],"domain_scores_gemma":[0.9993865,0.00003991662,0.0001441786,0.0003670914,0.00004580361,0.00001654204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001653064,0.00003915351,0.0001274284,0.00002357853,0.000008880745,7.942315e-7,0.00002484519,0.002400198,0.9932464,0.0003405455,0.00001893331,0.003752757],"study_design_scores_gemma":[0.0001665556,0.0001394792,0.00009503194,0.00003650581,0.000005663832,0.000006700239,0.0001093665,0.002235255,0.9956138,0.0008842708,0.0005677138,0.0001397152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9043438,0.001640918,0.09335743,0.0002681051,0.00003758332,0.0003004756,0.000005543507,0.00003165318,0.00001452767],"genre_scores_gemma":[0.9611861,0.001296664,0.03740727,0.00003588001,0.00002195701,0.00001975792,0.00001743842,0.00001259987,0.000002344882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05684232,"threshold_uncertainty_score":0.5122944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006945992820782576,"score_gpt":0.2399870095930971,"score_spread":0.2330410167723145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}