{"id":"W1521360902","doi":"10.1111/j.1742-4658.2007.05666.x","title":"The propeptide of cruzipain − a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F","year":2007,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Biotechnology Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Proteases; Protein precursor; Papain; Cathepsin; Biochemistry; Cathepsin B; Cathepsin C; Cathepsin O; Cathepsin L; Cathepsin H; Enzyme; Cathepsin S; Biology; Cathepsin A; Cysteine; Trypanosoma brucei; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005025163,0.0001445287,0.0002919833,0.0001021641,0.0005628811,0.00003415912,0.0003130864,0.00008090594,0.0000167741],"category_scores_gemma":[0.001980587,0.00006535203,0.0001684372,0.0003820499,0.0009804107,0.00007103512,0.0001822328,0.0005926321,3.99211e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007599761,"about_ca_system_score_gemma":0.0003074604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001174002,"about_ca_topic_score_gemma":0.0002581936,"domain_scores_codex":[0.9979195,0.000320509,0.0006172523,0.0001606072,0.00062237,0.0003597526],"domain_scores_gemma":[0.9977456,0.000513829,0.0006855372,0.0004138203,0.0004681617,0.000173041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002961902,0.0002273048,0.04081979,0.00007754059,0.0001700258,0.000004583318,0.001875485,0.000001399895,0.9429482,0.002506667,0.005420426,0.005652447],"study_design_scores_gemma":[0.0009267122,0.0004246392,0.7298662,0.0002123961,0.00005474129,0.00038145,0.001251657,0.000014957,0.2633823,0.000713838,0.002711853,0.00005924155],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914456,0.002510683,0.00009250038,0.004322841,0.0000643669,0.0006394539,0.00002506446,0.000005560481,0.0008939561],"genre_scores_gemma":[0.9981674,0.0002192014,0.000208878,0.0001018967,0.0002229366,0.000008173731,6.297648e-7,0.00001709926,0.001053795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6890464,"threshold_uncertainty_score":0.4329283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586792535144787,"score_gpt":0.2908471093836939,"score_spread":0.274979184032246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}