{"id":"W1521360902","doi":"10.1111/j.1742-4658.2007.05666.x","title":"The propeptide of cruzipain − a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F","year":2007,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Biotechnology Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Proteases; Protein precursor; Papain; Cathepsin; Biochemistry; Cathepsin B; Cathepsin C; Cathepsin O; Cathepsin L; Cathepsin H; Enzyme; Cathepsin S; Biology; Cathepsin A; Cysteine; Trypanosoma brucei; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009672032,0.0002904066,0.0002049483,0.00009644697,0.00007722656,0.0001284738,0.000166943,0.0002340124,0.001023908],"category_scores_gemma":[0.0001360397,0.00008915665,0.0001248882,0.00007456313,0.0001545628,0.0001415189,0.0001249517,0.0003766039,0.0003547058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070546,"about_ca_system_score_gemma":0.0001587922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002113043,"about_ca_topic_score_gemma":0.0002819741,"domain_scores_codex":[0.9999495,0.0000112049,0.00000396984,0.0000094538,0.00001617456,0.000009725408],"domain_scores_gemma":[0.999925,0.00002141457,0.00001929737,0.00000608256,0.000006628361,0.00002144451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002253969,0.00002385497,0.0001047618,0.00007640581,0.000005733404,0.0001617179,0.00000572226,0.00009012262,0.9961179,0.00008858817,0.00004560751,0.00305425],"study_design_scores_gemma":[0.00006941146,0.001618485,0.002006844,0.00001120444,0.00001860102,0.002455178,0.000009638761,0.0003960097,0.9873284,0.0000758757,0.006005503,0.000004818151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793131,0.01157575,0.005280514,0.0001359368,0.00005206203,0.00008077532,0.0003806486,0.00004086949,0.003140426],"genre_scores_gemma":[0.9834682,0.003805131,0.008459811,0.0001146672,0.00003377919,0.00004825429,0.001037356,0.00001105881,0.003021813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023908,"threshold_uncertainty_score":0.00342536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586792535144787,"score_gpt":0.2908471093836939,"score_spread":0.274979184032246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}