{"id":"W1521626316","doi":"10.1111/j.1365-2443.2005.00827.x","title":"Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3β phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease","year":2005,"lang":"en","type":"article","venue":"Genes to Cells","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":409,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; RIKEN Brain Science Institute; RIKEN; Ministry of Education, Culture, Sports, Science and Technology; Core Research for Evolutional Science and Technology; Japan Science and Technology Corporation; Yale University","keywords":"Cyclin-dependent kinase 5; Phosphorylation; Biology; GSK-3; Kinase; Cell biology; SEMA3A; Tau protein; Hyperphosphorylation; Protein kinase A; Neuroscience; Cyclin-dependent kinase 2; Biochemistry; Internal medicine; Receptor; Alzheimer's disease; Semaphorin; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008933792,0.0004250132,0.0001681925,0.0001921949,0.0001845465,0.000281012,0.0001526225,0.0001685494,0.001423829],"category_scores_gemma":[0.00007355773,0.0001342662,0.000315115,0.0001140789,0.0001859942,0.0002309141,0.0002107976,0.0002913745,0.0003223286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004710971,"about_ca_system_score_gemma":0.0002630118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00100831,"about_ca_topic_score_gemma":0.001680827,"domain_scores_codex":[0.9999321,0.000006161068,0.000004950425,0.00002068532,0.00001212642,0.00002398013],"domain_scores_gemma":[0.9999541,0.00000301645,0.0000161331,0.000004041291,0.000005288081,0.00001744444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002778481,0.00002327534,0.0009147659,0.00008515998,0.00001349868,0.0002153162,0.00001483606,0.00007651257,0.9966797,0.000160474,0.000074361,0.00146416],"study_design_scores_gemma":[0.00006686272,0.0002208147,0.06223595,0.00001826859,0.00003181016,0.001248691,0.00005754969,0.001378935,0.932022,0.0002460548,0.002461543,0.00001153542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916719,0.004281681,0.00131898,0.00009861442,0.00002677502,0.00001798262,0.0002977866,0.00006708284,0.002219255],"genre_scores_gemma":[0.9962583,0.001166705,0.0007317757,0.0000429824,0.00001074921,0.00002141302,0.0003903053,0.000007695442,0.001370055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423829,"threshold_uncertainty_score":0.004763186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05195120543255229,"score_gpt":0.2934215767827419,"score_spread":0.2414703713501896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}