{"id":"W1521770510","doi":"10.1002/path.4218","title":"Cancer‐generated lactic acid: a regulatory, immunosuppressive metabolite?","year":2013,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":345,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Canadian Institutes of Health Research; BC Cancer Foundation; Recruitment Program of Global Experts; National Natural Science Foundation of China","keywords":"Lactic acid; Immune system; Glutamine; Metabolite; Cancer; Cancer research; Secretion; Cancer cell; Biology; Metabolism; Biochemistry; Chemistry; Immunology; Amino acid; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008592513,0.000472585,0.001716641,0.0001594043,0.0001140357,0.00003144408,0.0009019103,0.0006003356,0.0001269379],"category_scores_gemma":[0.000167132,0.000278669,0.0007126391,0.000179831,0.0002487308,0.000009426677,0.0002104826,0.0007146558,0.0000282649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004430731,"about_ca_system_score_gemma":0.000910837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002471727,"about_ca_topic_score_gemma":0.00001102939,"domain_scores_codex":[0.9969376,0.001161083,0.0009727198,0.0002782981,0.0002243858,0.0004258863],"domain_scores_gemma":[0.9967992,0.00005173513,0.00184556,0.0007585724,0.0004089744,0.0001359404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000101473,0.0000672276,0.000001194567,0.0008180913,0.001227757,0.00004209182,0.0001292444,0.000006041849,0.0642442,0.00004234987,0.02817174,0.9051486],"study_design_scores_gemma":[0.0004434272,0.0001692251,0.00001318394,0.0004657533,0.002562958,0.004365045,0.00003237679,3.677204e-7,0.004346426,0.00002959182,0.9872858,0.0002858731],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00139052,0.9919959,0.00008013528,0.00006485025,0.005914128,0.000354631,0.00009074818,0.000005312957,0.0001037487],"genre_scores_gemma":[0.0001585738,0.9902286,0.0001643939,0.0001772114,0.007802762,0.00005761695,0.0000554311,0.0000776707,0.001277766],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.959114,"threshold_uncertainty_score":0.9999666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630901452163627,"score_gpt":0.3168914863783882,"score_spread":0.290582471856752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}