{"id":"W1521770510","doi":"10.1002/path.4218","title":"Cancer‐generated lactic acid: a regulatory, immunosuppressive metabolite?","year":2013,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":345,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Canadian Institutes of Health Research; BC Cancer Foundation; Recruitment Program of Global Experts; National Natural Science Foundation of China","keywords":"Lactic acid; Immune system; Glutamine; Metabolite; Cancer; Cancer research; Secretion; Cancer cell; Biology; Metabolism; Biochemistry; Chemistry; Immunology; Amino acid; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003908042,0.0007370071,0.001387878,0.001327257,0.0002810425,0.00112857,0.0008415018,0.00147746,0.002404595],"category_scores_gemma":[0.0003775522,0.0002823612,0.000299931,0.001354745,0.0008497487,0.001667076,0.0006278167,0.001946709,0.002553728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008465617,"about_ca_system_score_gemma":0.0007165806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008243003,"about_ca_topic_score_gemma":0.001544975,"domain_scores_codex":[0.9998972,0.00001794393,0.00001263245,0.00002111229,0.00003452475,0.00001644587],"domain_scores_gemma":[0.9998487,0.00005006702,0.00002364191,0.000006182308,0.00004513802,0.00002620058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001387111,0.00005254077,0.0002231311,0.009273537,0.00005483336,0.0005196749,0.00005738973,0.0002892318,0.00520676,0.007573718,0.03022778,0.9463828],"study_design_scores_gemma":[0.00001437698,0.00005732281,0.0004973667,0.001128918,0.0000369162,0.002381478,0.00005825651,0.00007323865,0.001289743,0.003247652,0.991198,0.00001680135],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001019398,0.9984657,0.0001315041,0.000453304,0.0002131844,0.000001697151,0.000008316241,0.000005776914,0.0006186475],"genre_scores_gemma":[0.001014923,0.9976052,0.0001360867,0.000278753,0.0002320709,0.000003952945,0.00001686894,0.000001558117,0.0007105498],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002404595,"threshold_uncertainty_score":0.008044183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630901452163627,"score_gpt":0.3168914863783882,"score_spread":0.290582471856752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}