{"id":"W1522866020","doi":"10.4049/jimmunol.176.4.2455","title":"Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":558,"is_retracted":false,"has_abstract":true,"ca_institutions":"Michael Smith Health Research BC; Simon Fraser University; Canada's Michael Smith Genome Sciences Centre; Institute of Infection and Immunity; University of British Columbia","funders":"Genome Prairie; Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC","keywords":"Proinflammatory cytokine; TLR2; Chemokine; Tumor necrosis factor alpha; Inflammation; Lipopolysaccharide; Biology; NF-κB; Cathelicidin; Cytokine; Cell biology; TLR4; Innate immune system; Immunology; Immune system; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348915,0.0003778671,0.0002626527,0.0001061232,0.0001097929,0.0003813046,0.0001523325,0.0001671737,0.001090922],"category_scores_gemma":[0.0002038681,0.00009621373,0.0002118126,0.00009873994,0.0003640379,0.00013859,0.0002309663,0.0003088482,0.0003796555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003861405,"about_ca_system_score_gemma":0.0002840574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004076763,"about_ca_topic_score_gemma":0.0004178789,"domain_scores_codex":[0.9998097,0.00005803265,0.00001752515,0.00002256812,0.00003550097,0.00005675978],"domain_scores_gemma":[0.9999343,0.00001478491,0.00001886241,0.000008170948,0.000006067617,0.00001783765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004375613,0.00003096232,0.0002260766,0.000090799,0.000006724062,0.00007325781,0.00001338023,0.00009675122,0.9962636,0.00006504794,0.00005403104,0.002641909],"study_design_scores_gemma":[0.00003633793,0.0008666184,0.003027999,0.00001829076,0.00002940508,0.0004923255,0.00004124269,0.0005511764,0.9912175,0.00009074512,0.003622615,0.00000568911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824943,0.01183584,0.003309899,0.0002361858,0.00006632183,0.00005102525,0.0004283393,0.00007793931,0.001500183],"genre_scores_gemma":[0.9935521,0.003055036,0.00213461,0.00007896644,0.00002272137,0.0000387065,0.0002756707,0.00000779831,0.0008344676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090922,"threshold_uncertainty_score":0.003649473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014257052625403,"score_gpt":0.2022398934511896,"score_spread":0.1920973229249356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}