{"id":"W1522955826","doi":"10.1111/j.1747-0285.2010.00955.x","title":"Identification and Characterization of Novel Nrf2 Inducers Designed to Target the Intervening Region of Keap1","year":2010,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Identification (biology); KEAP1; Inducer; Computational biology; Characterization (materials science); Chemistry; Biology; Biochemistry; Nanotechnology; Materials science; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211201,0.0002883435,0.0003528343,0.0001640542,0.0001018475,0.0001648141,0.0002144833,0.0001772378,0.000959767],"category_scores_gemma":[0.0001447946,0.0001543462,0.0002253216,0.0002307207,0.00008351228,0.0001264225,0.0001195402,0.0002893205,0.0003694952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002278397,"about_ca_system_score_gemma":0.0001847555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003233267,"about_ca_topic_score_gemma":0.0005452402,"domain_scores_codex":[0.9999349,0.00001053062,0.000006520561,0.00001329327,0.0000244565,0.0000102948],"domain_scores_gemma":[0.9999363,0.000007583033,0.00002034214,0.000006931261,0.00001062688,0.00001814892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008420814,0.00005268626,0.0001214059,0.00004734875,0.000004052597,0.00003032392,0.000005984629,0.0005509906,0.9971892,0.00005387348,0.00003013369,0.001829881],"study_design_scores_gemma":[0.00003006077,0.0004976665,0.0008506271,0.000003583446,0.00001624861,0.0001155834,0.000008895367,0.001515839,0.9939085,0.00002629815,0.003021756,0.000004848958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918076,0.001683265,0.00436986,0.00008142265,0.00001198688,0.00008134628,0.0006614585,0.0001031104,0.001199944],"genre_scores_gemma":[0.9810767,0.001585505,0.01300126,0.0000586787,0.000009243096,0.00006317041,0.002364962,0.00003945875,0.001801054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000959767,"threshold_uncertainty_score":0.003210723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694649662160652,"score_gpt":0.2522658463816299,"score_spread":0.2353193497600233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}