{"id":"W1522955826","doi":"10.1111/j.1747-0285.2010.00955.x","title":"Identification and Characterization of Novel Nrf2 Inducers Designed to Target the Intervening Region of Keap1","year":2010,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Identification (biology); KEAP1; Inducer; Computational biology; Characterization (materials science); Chemistry; Biology; Biochemistry; Nanotechnology; Materials science; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003007507,0.0001316007,0.0001882282,0.00003939533,0.00003592912,0.000007738744,0.000264391,0.0001965889,0.000004416508],"category_scores_gemma":[0.0002865725,0.0001064371,0.00005913091,0.00008227341,0.0003232177,0.000005168949,0.0001129239,0.0001254469,9.899614e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006257876,"about_ca_system_score_gemma":0.0000321822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005425832,"about_ca_topic_score_gemma":9.431956e-7,"domain_scores_codex":[0.9990805,0.00006908399,0.0003314714,0.0003198392,0.00004626602,0.0001528372],"domain_scores_gemma":[0.9992091,0.00005628837,0.0002369936,0.0002954133,0.0001419976,0.00006020441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001190386,0.00005365434,0.0007111709,0.00001575304,0.00003102868,1.210418e-7,0.0001875271,0.000002185993,0.9976471,0.0001073027,0.00009543433,0.001029702],"study_design_scores_gemma":[0.000274736,0.00006210483,0.001135773,0.00001273764,0.00001583215,0.000007307989,0.00004260528,0.00004583661,0.9977725,0.0001768196,0.0003440391,0.0001097056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9170772,0.00005589566,0.0821662,0.0002761289,0.000107596,0.0002655228,0.00002398768,0.000005405155,0.00002205808],"genre_scores_gemma":[0.9957504,0.00002315103,0.003751314,0.0001164441,0.0001064279,0.00003104499,0.0001656016,0.00001328699,0.00004236008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07867316,"threshold_uncertainty_score":0.4340377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694649662160652,"score_gpt":0.2522658463816299,"score_spread":0.2353193497600233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}