{"id":"W1523241089","doi":"10.1002/9780470929353.ch16","title":"Discovery and Development of BILN 2061 and Follow‐Up BI 201335","year":2011,"lang":"en","type":"other","venue":"","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Clinical trial; Cardiotoxicity; In vivo; Potency; Drug discovery; Computational biology; Medicine; In vitro; Biology; Bioinformatics; Internal medicine; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003084251,0.0006673994,0.0002935858,0.0007001301,0.0002745892,0.000545345,0.0004457562,0.0003731658,0.01159435],"category_scores_gemma":[0.0001515472,0.0002244099,0.0003017494,0.0003438085,0.0001404039,0.0004375679,0.0004522594,0.0009605007,0.007434278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008029447,"about_ca_system_score_gemma":0.0007474611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103724,"about_ca_topic_score_gemma":0.002810499,"domain_scores_codex":[0.9998727,0.00001216553,0.000007225514,0.00001836694,0.00006620303,0.00002338982],"domain_scores_gemma":[0.9999614,0.000002524851,0.000006558984,0.000003153524,0.00001262683,0.00001376701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008332299,0.000575487,0.0003349791,0.001134361,0.00003450146,0.000473116,0.00009540932,0.001383758,0.5981113,0.01274446,0.04089971,0.3433798],"study_design_scores_gemma":[0.0001093937,0.001249733,0.000848739,0.0001323005,0.00003838944,0.0009589356,0.00002005252,0.0009653227,0.3954546,0.0008462134,0.5993457,0.00003052482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.2213969,0.1388118,0.0941228,0.005519479,0.002346016,0.003083594,0.01711029,0.003573595,0.5140356],"genre_scores_gemma":[0.3236915,0.1246683,0.08837919,0.003523197,0.0002285463,0.001333358,0.02212811,0.0005748064,0.435473],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01159435,"threshold_uncertainty_score":0.03878701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1359945858491095,"score_gpt":0.4034073842049368,"score_spread":0.2674127983558273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}