{"id":"W1523259903","doi":"10.1139/y10-060","title":"Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytesThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Bosentan; Multidrug resistance-associated protein 2; Bile Salt Export Pump; Pharmacology; Chemistry; Efflux; Ambrisentan; Organic anion transporter 1; Transporter; Probenecid; Organic anion-transporting polypeptide; P-glycoprotein; Biochemistry; ATP-binding cassette transporter; Endothelin receptor; Receptor; Biology; Multiple drug resistance","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000421332,0.0004771606,0.0007139287,0.0001682634,0.0001621039,0.0003689505,0.0003223962,0.0003387491,0.001208029],"category_scores_gemma":[0.0004222576,0.0003242417,0.0004072135,0.0002829056,0.0001466065,0.0003674825,0.0001579305,0.0006533428,0.0003456166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002598651,"about_ca_system_score_gemma":0.0003820888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000789828,"about_ca_topic_score_gemma":0.002779094,"domain_scores_codex":[0.9996542,0.0001428645,0.00004524408,0.00004858311,0.00007791433,0.00003121179],"domain_scores_gemma":[0.999743,0.00007434824,0.00005510142,0.00002391709,0.0000691639,0.000034527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003248086,0.000602776,0.0009277512,0.0003186713,0.0001647797,0.0001814403,0.0000796818,0.000848458,0.977523,0.000112042,0.0003292622,0.01566403],"study_design_scores_gemma":[0.0007404127,0.01750612,0.008917797,0.00002357346,0.0003255706,0.0007090264,0.0001285926,0.003233572,0.9637277,0.00004963054,0.004600683,0.00003719067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701558,0.02335269,0.002183332,0.0003072596,0.0001768933,0.0001511731,0.0008046479,0.00008507354,0.002783175],"genre_scores_gemma":[0.9725612,0.01431187,0.007521185,0.0001980563,0.00007123121,0.0001954995,0.001589594,0.0000295816,0.003521688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001208029,"threshold_uncertainty_score":0.004041314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02430815007179882,"score_gpt":0.3196553765604122,"score_spread":0.2953472264886134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}