{"id":"W1523483559","doi":"10.1007/978-1-60327-483-8_8","title":"Cre Recombinase Mediated Alterations of the Mouse Genome Using Embryonic Stem Cells","year":2008,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute","keywords":"Cre recombinase; Recombinase; Cre-Lox recombination; Biology; Homologous recombination; Site-specific recombination; Genetics; Genome; FLP-FRT recombination; DNA; Gene; Embryonic stem cell; Gene targeting; Transgene; Recombination; Genetic recombination; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004876616,0.0004258546,0.001044206,0.000182639,0.00006007147,0.000007847838,0.0006076846,0.0007304733,0.00001199886],"category_scores_gemma":[0.0001319747,0.000332846,0.0005690072,0.0003874002,0.00016617,0.000001267362,0.0003636479,0.0003796468,0.00000226475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005206163,"about_ca_system_score_gemma":0.0002800343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001512316,"about_ca_topic_score_gemma":0.000007648749,"domain_scores_codex":[0.9965693,0.001672018,0.000720945,0.0005838908,0.00007791862,0.0003758685],"domain_scores_gemma":[0.9985006,0.00008905248,0.0003264184,0.0009537261,0.00006323248,0.00006691716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003510203,0.00004974288,0.000004839459,0.0008272715,0.0001750408,0.000008647178,0.00002164817,0.0007975749,0.9462302,0.00003684503,0.00002895957,0.05181567],"study_design_scores_gemma":[0.0003020232,0.0001263962,0.000001375991,0.0003139986,0.000185583,0.0001189624,0.00001113129,0.0001502606,0.2804887,0.00002222004,0.7177606,0.0005187998],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004724677,0.7222738,0.2763861,0.00000487884,0.0002531728,0.0004890675,0.00007538604,0.000007047956,0.00003808813],"genre_scores_gemma":[0.00001523142,0.8808563,0.1184905,0.00003853254,0.00005871532,0.00005721981,0.0002106548,0.00007311054,0.0001998167],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7177316,"threshold_uncertainty_score":0.9999124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04277755878059333,"score_gpt":0.4343561894704684,"score_spread":0.3915786306898751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}