{"id":"W1523615188","doi":"10.1186/ar1381","title":"Regulation of innate and adaptive immunity and autoimmunity by Toll-like receptor 9","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"TLR9; Immunology; Autoimmunity; Immune system; CpG Oligodeoxynucleotide; Acquired immune system; Disease; Medicine; Antigen; Immunotherapy; Cancer immunotherapy; Biology; Clinical trial; Bioinformatics; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001310088,0.00009638065,0.0001957987,0.0001851345,0.0004172532,0.00002071581,0.0001105615,0.0001905046,0.0001778213],"category_scores_gemma":[0.0002210057,0.00009641589,0.00002422441,0.0002045929,0.0008025851,0.0002454803,0.0001774778,0.0004695125,0.00008116339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004269198,"about_ca_system_score_gemma":0.0000863093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113118,"about_ca_topic_score_gemma":0.00006552779,"domain_scores_codex":[0.9984142,0.0007812612,0.0002639673,0.0001727853,0.00008095709,0.00028688],"domain_scores_gemma":[0.999201,0.0002385425,0.00006508071,0.0002412306,0.0002324848,0.00002166745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004360334,0.00006441138,0.0001722861,0.00001296615,0.00004110219,9.290179e-7,0.001309998,0.000001268217,0.9250992,0.00324731,0.0009724135,0.06864209],"study_design_scores_gemma":[0.003539649,0.001052116,0.05094022,0.0002348101,0.00000535079,0.00007311184,0.001398421,0.000008030205,0.9111971,0.003820931,0.02754182,0.000188469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821903,0.01604179,0.00004910124,0.0004857328,0.00007568909,0.0002625836,0.0000189506,0.00002359718,0.0008522855],"genre_scores_gemma":[0.9935591,0.005298418,0.00009845039,0.00001432007,0.000005947758,0.00001971383,0.0001075158,0.000009628544,0.0008868624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06845363,"threshold_uncertainty_score":0.3931726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473399126861568,"score_gpt":0.2878423621402361,"score_spread":0.2631083708716204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}