{"id":"W1523615188","doi":"10.1186/ar1381","title":"Regulation of innate and adaptive immunity and autoimmunity by Toll-like receptor 9","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"TLR9; Immunology; Autoimmunity; Immune system; CpG Oligodeoxynucleotide; Acquired immune system; Disease; Medicine; Antigen; Immunotherapy; Cancer immunotherapy; Biology; Clinical trial; Bioinformatics; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00183085,0.000332103,0.0003943412,0.001024591,0.0001819239,0.0006364748,0.0002261677,0.0002936409,0.001246636],"category_scores_gemma":[0.0008407123,0.0001424014,0.0004233535,0.0003227505,0.0004364532,0.0004233771,0.000495819,0.0005066313,0.0003997305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003528901,"about_ca_system_score_gemma":0.0005162113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002811524,"about_ca_topic_score_gemma":0.0004004083,"domain_scores_codex":[0.9989637,0.000661432,0.00008380919,0.00007138017,0.0001320343,0.0000875209],"domain_scores_gemma":[0.9994418,0.0001924137,0.0001914576,0.00002444194,0.0001083715,0.00004145168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002037998,0.0004237037,0.03091755,0.005931093,0.0002789106,0.002119204,0.0005072385,0.001656897,0.3528633,0.01274643,0.00946608,0.5810516],"study_design_scores_gemma":[0.0007707982,0.005550205,0.2865908,0.003003029,0.0005817869,0.009333796,0.001621249,0.004204799,0.3761703,0.01396954,0.2980449,0.0001588499],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4019485,0.5383275,0.02400514,0.007255665,0.001235534,0.0003964852,0.00137108,0.0002366292,0.02522356],"genre_scores_gemma":[0.8201297,0.1504104,0.01764487,0.001398201,0.0003761226,0.0002304174,0.0006245461,0.00002205224,0.009163663],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00183085,"threshold_uncertainty_score":0.009682536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473399126861568,"score_gpt":0.2878423621402361,"score_spread":0.2631083708716204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}