{"id":"W1523878115","doi":"10.1038/nbt.3231","title":"Oversight of human inheritable genome modification","year":2015,"lang":"en","type":"letter","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"","keywords":"Human genome; Genome; Computational biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.009269309,0.0005858559,0.0008190173,0.0003920567,0.002721128,0.003746388,0.001947582,0.04744684,0.00352576],"category_scores_gemma":[0.0284143,0.0005256206,0.001051858,0.0002440291,0.007236528,0.002741347,0.003290721,0.0336557,0.001507665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004071982,"about_ca_system_score_gemma":0.005244769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004248753,"about_ca_topic_score_gemma":0.009189482,"domain_scores_codex":[0.992049,0.001740389,0.0005089155,0.001034029,0.003446155,0.001221484],"domain_scores_gemma":[0.986576,0.008135203,0.0007323388,0.0008669188,0.001466132,0.002223381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009805583,0.00005033436,0.0006666378,0.00006759264,0.00004767961,0.001291324,0.0001745755,0.0002168479,0.001202826,0.05275468,0.9092603,0.03416917],"study_design_scores_gemma":[0.0001408704,0.0001230518,0.001134219,0.0001620665,0.00005650938,0.001983745,0.0001819076,0.0007864829,0.002414512,0.07451647,0.9184319,0.00006821456],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0009622945,0.003682109,0.001612892,0.9663232,0.0186949,0.00001084222,0.0000346093,0.00009060795,0.008588571],"genre_scores_gemma":[0.01922365,0.001605684,0.0009087239,0.9529983,0.01548662,0.00003152094,0.00003018985,0.00002797553,0.009687394],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9525532,"threshold_uncertainty_score":0.04902142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104240629967711,"score_gpt":0.2944461743291066,"score_spread":0.2840221113323355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}