{"id":"W152421523","doi":"10.1038/ja.2006.74","title":"Genomic Analyses Lead to Novel Secondary Metabolites","year":2006,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aptose Biosciences (Canada); Concordia University","funders":"","keywords":"Polyketide; Stereochemistry; Glycosidic bond; Chemistry; Amide; Gene cluster; Biology; Gene; Microbiology; Biochemistry; Biosynthesis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004733707,0.0001086905,0.000332934,0.0001366567,0.00006490852,0.00002264388,0.0001635806,0.00004581474,0.00009295881],"category_scores_gemma":[0.0001121873,0.00005452598,0.0001382764,0.0002186767,0.00006057235,0.00005041956,0.00003670664,0.0002550052,0.00003592938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002588839,"about_ca_system_score_gemma":0.00008646942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005472021,"about_ca_topic_score_gemma":0.00001009807,"domain_scores_codex":[0.9991762,0.00002994161,0.000380939,0.00007310943,0.0001763879,0.0001634353],"domain_scores_gemma":[0.9992493,0.000071763,0.0002080731,0.0001836535,0.0002244163,0.00006275035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001592464,0.0001170717,0.000469899,0.00002231115,0.0001047935,0.00001052202,0.00004127377,0.00004218749,0.9892711,0.00005443728,0.008436537,0.001270601],"study_design_scores_gemma":[0.000421191,0.0001765929,0.03124245,0.00005886688,0.0005373074,0.0005213043,0.00007747183,0.0000153068,0.9500916,0.00004094289,0.01674002,0.00007692699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904339,0.002425872,0.0002703529,0.005933984,0.0002159409,0.00009265976,0.00001288701,0.000006796274,0.0006076507],"genre_scores_gemma":[0.9904632,0.0002140009,0.006222744,0.001002304,0.0009878384,2.193276e-10,0.00000162025,0.00001278243,0.001095509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0391795,"threshold_uncertainty_score":0.2223505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03250259806355745,"score_gpt":0.2960101341443913,"score_spread":0.2635075360808339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}