{"id":"W152421523","doi":"10.1038/ja.2006.74","title":"Genomic Analyses Lead to Novel Secondary Metabolites","year":2006,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aptose Biosciences (Canada); Concordia University","funders":"","keywords":"Polyketide; Stereochemistry; Glycosidic bond; Chemistry; Amide; Gene cluster; Biology; Gene; Microbiology; Biochemistry; Biosynthesis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578435,0.0007415391,0.0005519142,0.0005631227,0.0002459841,0.0007377969,0.0002173079,0.0005543898,0.001866738],"category_scores_gemma":[0.0005061033,0.0002016463,0.0006845353,0.0005720576,0.0003608399,0.0002026918,0.0003090718,0.0008687712,0.001105376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250879,"about_ca_system_score_gemma":0.0003040046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005313235,"about_ca_topic_score_gemma":0.0008999231,"domain_scores_codex":[0.9998174,0.00004070852,0.00001415003,0.00003954487,0.00004732315,0.00004080382],"domain_scores_gemma":[0.9996241,0.0001363819,0.00007389613,0.00003112441,0.00005784127,0.00007669209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003386645,0.00006256173,0.0008658706,0.00005569097,0.00001356358,0.000575261,0.00002741384,0.000151574,0.9945702,0.0001622548,0.0001201369,0.003056814],"study_design_scores_gemma":[0.00004926091,0.0005211344,0.01676498,0.00002266355,0.0001415726,0.001306958,0.0002298233,0.0009651139,0.9735772,0.0004970651,0.005903374,0.00002085496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650987,0.00196369,0.01981801,0.001072221,0.0002288912,0.0001788519,0.00646429,0.0004163641,0.004758838],"genre_scores_gemma":[0.9777955,0.001002376,0.01278523,0.0003111312,0.00007753639,0.00005993999,0.006035296,0.00007950405,0.001853607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001866738,"threshold_uncertainty_score":0.006244838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03250259806355745,"score_gpt":0.2960101341443913,"score_spread":0.2635075360808339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}