{"id":"W1525657691","doi":"10.4049/jimmunol.177.2.1085","title":"Grb2 and Gads Exhibit Different Interactions with CD28 and Play Distinct Roles in CD28-Mediated Costimulation","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"NFAT; CD28; Mutant; GRB2; Cell biology; Chemistry; PI3K/AKT/mTOR pathway; Cytoplasm; Wild type; Biology; Molecular biology; Signal transduction; Biochemistry; Transcription factor; Signal transducing adaptor protein; In vitro; Gene; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001069832,0.0004723375,0.0002639588,0.000207436,0.0001033984,0.0004537297,0.0002773492,0.0002385947,0.0007431078],"category_scores_gemma":[0.0001065715,0.0001961374,0.0003672527,0.0001981574,0.0002633588,0.0002509106,0.0003642803,0.0004072803,0.0002882676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993105,"about_ca_system_score_gemma":0.0001162443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003187262,"about_ca_topic_score_gemma":0.000428584,"domain_scores_codex":[0.9998237,0.00001837073,0.00001625943,0.00004443012,0.00004033731,0.00005701725],"domain_scores_gemma":[0.9998848,0.000008268738,0.00003058146,0.00001654919,0.00001049436,0.0000492464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001892559,0.00002668324,0.001262376,0.00003637489,0.00001299732,0.00009204327,0.00001705465,0.0001260574,0.996094,0.0002956216,0.0000250256,0.001822503],"study_design_scores_gemma":[0.0000750506,0.0003768547,0.02811427,0.0000131144,0.00004933824,0.00213088,0.00009594286,0.002922135,0.960456,0.000200009,0.005552154,0.00001429548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964126,0.001042329,0.001565951,0.00003277326,0.000009552307,0.000006543366,0.00007585078,0.00003273939,0.0008217581],"genre_scores_gemma":[0.996117,0.0003896969,0.001566726,0.00003694007,0.000006368672,0.00001480889,0.0004159861,0.00001430255,0.001438102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007431078,"threshold_uncertainty_score":0.002485991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005476343041063547,"score_gpt":0.214846817966632,"score_spread":0.2093704749255685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}