{"id":"W1525771749","doi":"10.18632/oncotarget.3036","title":"Predicting response to HER2 kinase inhibition","year":2014,"lang":"en","type":"letter","venue":"Oncotarget","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Kinase; Cancer research; Medicine; Lapatinib; Cancer; Oncology; Internal medicine; Biology; Trastuzumab; Breast cancer; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001828506,0.0004190492,0.0007180497,0.0005334467,0.0001230271,0.00007289519,0.0002357141,0.001003803,0.001587818],"category_scores_gemma":[0.001735267,0.0003997174,0.0002157424,0.0004358719,0.00009492189,0.0000577284,0.0001737895,0.003249126,0.00259754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001029026,"about_ca_system_score_gemma":0.0007949293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000300113,"about_ca_topic_score_gemma":0.00001997462,"domain_scores_codex":[0.9956138,0.0006088792,0.00052624,0.0008348426,0.001486425,0.0009298119],"domain_scores_gemma":[0.9975412,0.0005155999,0.0001416132,0.001092326,0.0003044824,0.0004047557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001039296,0.00004092859,0.004227821,0.0005921574,0.00004545306,0.003141918,0.0002030627,0.000003235568,0.004279323,0.000001614443,0.9859225,0.0005027087],"study_design_scores_gemma":[0.0009531017,0.001163311,0.001846278,0.00146968,0.00006356328,0.0001602238,0.00001747697,0.00005715628,0.00168839,0.00004626268,0.9921837,0.000350858],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.08900363,0.0001686068,0.0001390272,0.8976897,0.0007615699,0.00124032,0.000118176,0.0002597259,0.01061927],"genre_scores_gemma":[0.01038094,0.00002535753,0.001840946,0.9357033,0.01602786,0.0003187795,0.0007166237,0.0002554854,0.03473075],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07862269,"threshold_uncertainty_score":0.9998454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106522826014464,"score_gpt":0.3567094642145497,"score_spread":0.3156442359544051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}