{"id":"W1526123135","doi":"10.1046/j.1471-4159.2002.00969.x","title":"Oxidative damage increases with age in a canine model of human brain aging","year":2002,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"National Institute of Environmental Health Sciences; National Institute on Aging","keywords":"Lipid peroxidation; Oxidative stress; Glutathione; Malondialdehyde; Endocrinology; Internal medicine; Oxidative phosphorylation; Prefrontal cortex; Brain damage; Chemistry; Human brain; Neuropathology; Biochemistry; Biology; Medicine; Neuroscience; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007565318,0.0001120169,0.0002887805,0.0001015109,0.00002559662,0.000008216468,0.00009391792,0.00003029922,0.00007917631],"category_scores_gemma":[0.0001197159,0.00008350301,0.00007217064,0.0001409253,0.00008935159,0.00008630892,0.00002706142,0.0002744292,9.025079e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005259025,"about_ca_system_score_gemma":0.0001065991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002602073,"about_ca_topic_score_gemma":0.000007809642,"domain_scores_codex":[0.9990439,0.00002772947,0.0002742677,0.0001088133,0.0003730553,0.0001721773],"domain_scores_gemma":[0.9992068,0.00005898643,0.0002043583,0.0001484145,0.0001338116,0.0002476218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005298089,0.002045704,0.05399284,0.0002490463,0.001314354,0.01109322,0.0003093082,0.0001752454,0.9289663,0.000004576589,0.001191784,0.0001277839],"study_design_scores_gemma":[0.03963964,0.00636171,0.3364713,0.004956562,0.002010878,0.004064693,0.001517616,0.01006573,0.5936294,0.0004354196,0.00004176854,0.000805309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972605,0.0006048225,0.000008326687,0.0003433818,0.000002533304,0.00006772259,0.00001067977,0.000004438491,0.001697649],"genre_scores_gemma":[0.9994036,0.0000543776,0.0002035404,0.0001016988,0.00004559261,0.000001871169,0.00000630651,0.00001492337,0.0001680974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.335337,"threshold_uncertainty_score":0.3405154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04280238100570925,"score_gpt":0.3148072112500153,"score_spread":0.2720048302443061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}