{"id":"W152636316","doi":"10.1023/a:1013181107707","title":"Intermittent Blood Flow in Solid Tumours – an under-appreciated Source of ‘drug Resistance’","year":2001,"lang":"en","type":"review","venue":"Cancer and Metastasis Reviews","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Drug resistance; Drug; Blood flow; Chemotherapy; Drug delivery; Medicine; Resistance (ecology); Intensive care medicine; Pharmacology; Cancer research; Biology; Internal medicine; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009912339,0.001188066,0.003120421,0.001761167,0.0005517603,0.002118592,0.001710356,0.003281019,0.002952483],"category_scores_gemma":[0.0008857602,0.0005200625,0.0004817831,0.002455666,0.001966781,0.003216931,0.0008462882,0.00329867,0.002593474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001037454,"about_ca_system_score_gemma":0.0009541557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094764,"about_ca_topic_score_gemma":0.001884505,"domain_scores_codex":[0.9996611,0.00006957307,0.00003935015,0.00006543244,0.0001321595,0.00003237905],"domain_scores_gemma":[0.9993741,0.0003114791,0.00007246489,0.00002587721,0.0001640955,0.00005215191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001783723,0.00006594967,0.0002027251,0.009474951,0.00008062865,0.0005274427,0.0001214949,0.0005786844,0.00799989,0.01150478,0.06444974,0.9048153],"study_design_scores_gemma":[0.0000422401,0.0001265813,0.0007227793,0.001048426,0.00008105911,0.002946391,0.0001146367,0.0002037577,0.001726618,0.006323787,0.9866273,0.00003643859],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001514462,0.9970121,0.0005052076,0.0008646191,0.0006648315,0.000004100344,0.00001021898,0.00001529659,0.0007722138],"genre_scores_gemma":[0.0009490981,0.9968268,0.000259292,0.0003809739,0.0008284329,0.000005989287,0.00001756683,0.000002603155,0.0007292108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003281019,"threshold_uncertainty_score":0.009877026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04611607092999819,"score_gpt":0.3467740470831054,"score_spread":0.3006579761531072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}