{"id":"W1526595001","doi":"10.1002/stem.1952","title":"Reversible Lineage-Specific Priming of Human Embryonic Stem Cells Can Be Exploited to Optimize the Yield of Differentiated Cells","year":2015,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Embryonic stem cell; Cell biology; Haematopoiesis; Cellular differentiation; Stem cell; Lineage (genetic); Priming (agriculture); Chemically defined medium; Lineage markers; Immunology; In vitro; Genetics; Progenitor cell; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000716646,0.0003568876,0.0005319241,0.0001779148,0.0001214273,0.00004451946,0.0009434472,0.0002728094,0.00005770316],"category_scores_gemma":[0.00000969272,0.0002915549,0.0002448681,0.0004175107,0.0001709325,0.000009024274,0.0006283066,0.0002598496,0.00003523956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000724789,"about_ca_system_score_gemma":0.0002063895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001634724,"about_ca_topic_score_gemma":0.00005320523,"domain_scores_codex":[0.9970759,0.0002937495,0.0006878725,0.0006612933,0.0006497531,0.0006314629],"domain_scores_gemma":[0.9976323,0.00009496866,0.0003555363,0.001132701,0.0004441272,0.0003403487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001669583,0.0001577954,0.00007476463,0.0001557228,0.0001113895,0.000007372279,0.0005927343,0.0009070074,0.9798878,0.000005234748,0.01771452,0.0002186573],"study_design_scores_gemma":[0.0008942478,0.0006050862,0.00002298276,0.0001289085,0.00004491815,0.000002079852,0.001984688,0.0001331685,0.9886733,0.000001669962,0.007211892,0.0002970734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957829,0.0008389674,0.0005455685,0.0001539978,0.0004465044,0.000969702,0.000155811,0.0000230908,0.001083493],"genre_scores_gemma":[0.9835608,0.0003186876,0.0002815224,0.00008877576,0.0001202761,0.00003045824,0.00005239198,0.00007034809,0.01547675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01439326,"threshold_uncertainty_score":0.9999537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06768071690665278,"score_gpt":0.2713661675207206,"score_spread":0.2036854506140678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}