{"id":"W1526595001","doi":"10.1002/stem.1952","title":"Reversible Lineage-Specific Priming of Human Embryonic Stem Cells Can Be Exploited to Optimize the Yield of Differentiated Cells","year":2015,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Embryonic stem cell; Cell biology; Haematopoiesis; Cellular differentiation; Stem cell; Lineage (genetic); Priming (agriculture); Chemically defined medium; Lineage markers; Immunology; In vitro; Genetics; Progenitor cell; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002947584,0.0004561187,0.0002270369,0.0002139532,0.0001141569,0.0003088432,0.0001914813,0.00022342,0.001418295],"category_scores_gemma":[0.0003102598,0.0001796216,0.0001599766,0.0001868652,0.000189941,0.0002096639,0.0003107251,0.0003822963,0.000614907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001460984,"about_ca_system_score_gemma":0.0001718843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000730079,"about_ca_topic_score_gemma":0.0002168916,"domain_scores_codex":[0.9998114,0.00004234504,0.00002534325,0.0000484597,0.0000510918,0.00002140744],"domain_scores_gemma":[0.9998651,0.00004812811,0.00003928147,0.00002458631,0.00001115531,0.00001173071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001603906,0.000005917544,0.00007266737,0.00001577202,9.505744e-7,0.00001754843,0.000007966617,0.00006682223,0.9986211,0.00009066068,0.0000151943,0.001069278],"study_design_scores_gemma":[0.000001768301,0.00003821935,0.0003763569,0.00000214205,0.000002762167,0.00003803303,0.000003720467,0.0001911321,0.9984048,0.00002547504,0.0009139069,0.000001677326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9507481,0.002751743,0.03905511,0.0001904954,0.00008268895,0.0002325877,0.0008460632,0.0004772181,0.005615911],"genre_scores_gemma":[0.9778525,0.001645184,0.01674847,0.00007375003,0.00002093741,0.0001524044,0.0005889883,0.0001410311,0.002776798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418295,"threshold_uncertainty_score":0.004744649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06768071690665278,"score_gpt":0.2713661675207206,"score_spread":0.2036854506140678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}