{"id":"W1526849981","doi":"10.1212/wnl.84.14_supplement.p7.240","title":"Rationale for EDSS-Plus, the Primary Composite Endpoint of Disability Progression in the ASCEND Phase 3 Study of Natalizumab for Secondary Progressive Multiple Sclerosis: A Post Hoc Analysis of IMPACT Study Data (P7.240)","year":2015,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Multiple sclerosis; Post-hoc analysis; Natalizumab; Medicine; Clinical endpoint; Post hoc; Physical therapy; Physical medicine and rehabilitation; Expanded Disability Status Scale; Internal medicine; Clinical trial; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04484517,0.001902915,0.002260742,0.0009037675,0.001028741,0.001311158,0.002537034,0.002798077,0.005193077],"category_scores_gemma":[0.01965385,0.001158328,0.002243186,0.0006699731,0.001725932,0.0008307556,0.0008079913,0.005125616,0.002507161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006456714,"about_ca_system_score_gemma":0.003539922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002797337,"about_ca_topic_score_gemma":0.0006162945,"domain_scores_codex":[0.9783052,0.01595165,0.00165204,0.001431846,0.002175904,0.0004832364],"domain_scores_gemma":[0.9911684,0.002861344,0.001894578,0.0009841665,0.001919403,0.001172122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6079763,0.008234618,0.02117687,0.01156939,0.004085654,0.001502075,0.0007783327,0.002524495,0.04959213,0.01745173,0.1159665,0.1591419],"study_design_scores_gemma":[0.5537016,0.137466,0.053837,0.002651786,0.003575266,0.001452474,0.000138362,0.006869611,0.01306283,0.009120598,0.2177719,0.0003525673],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.2311029,0.02876036,0.07719228,0.03167857,0.01713762,0.55231,0.03474121,0.001713437,0.02536358],"genre_scores_gemma":[0.3987571,0.004446057,0.1027569,0.02043443,0.006145912,0.4410145,0.01149163,0.0002767648,0.01467658],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04484517,"threshold_uncertainty_score":0.2371667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1808148887905743,"score_gpt":0.4376091188574238,"score_spread":0.2567942300668495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}