{"id":"W1527088201","doi":"10.1001/jamaoto.2013.3210","title":"High Frequency of Activating &lt;emph type=\"ital\"&gt;PIK3CA&lt;/emph&gt; Mutations in Human Papillomavirus–Positive Oropharyngeal Cancer&lt;alt-title&gt;&lt;emph type=\"ital\"&gt;PIK3CA&lt;/emph&gt; in HPV+ Oropharyngeal Squamous Cell Carcinoma&lt;/alt-title&gt;","year":2013,"lang":"en","type":"article","venue":"JAMA Otolaryngology–Head & Neck Surgery","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Hospital","funders":"","keywords":"Sanger sequencing; Mutation; Gene; Cancer; Oncogene; Head and neck squamous-cell carcinoma; Polymerase chain reaction; Human papillomavirus; Cancer research; Genotype; Stop codon; Molecular biology; Biology; Head and neck cancer; Medicine; Genetics; Internal medicine; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0009295153,0.001298875,0.001946197,0.0009083186,0.0004062075,0.0001541714,0.001162304,0.001582462,0.003268784],"category_scores_gemma":[0.0005819497,0.001398365,0.0006152708,0.001457628,0.0007296844,0.0002251151,0.0005473751,0.001150782,0.0007608404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007930132,"about_ca_system_score_gemma":0.001519028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001931283,"about_ca_topic_score_gemma":0.00169488,"domain_scores_codex":[0.9923146,0.0007775152,0.002080149,0.002030317,0.0008780116,0.001919432],"domain_scores_gemma":[0.9951953,0.0006718618,0.001104383,0.001594848,0.0008979001,0.0005357345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003321145,0.0007422632,0.04108082,0.0005291859,0.0002587193,0.0006564384,0.0004034754,0.0001614793,0.9242862,0.0006138766,0.02709406,0.003841298],"study_design_scores_gemma":[0.01071417,0.002827103,0.4057174,0.001704234,0.0007240062,0.000580054,0.0002464346,0.001675328,0.5128894,0.001479847,0.05434963,0.007092354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697682,0.01122394,0.00004163616,0.0003100419,0.002431532,0.001370491,0.0005889144,0.0001629919,0.0141023],"genre_scores_gemma":[0.9916317,0.0006071714,0.0007039835,0.0007458936,0.001411735,0.0004703385,0.001536236,0.0003618764,0.002531076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4113968,"threshold_uncertainty_score":0.9999763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403106833917789,"score_gpt":0.2564929254749554,"score_spread":0.2424618571357776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}