{"id":"W1527088201","doi":"10.1001/jamaoto.2013.3210","title":"High Frequency of Activating <emph type=\"ital\">PIK3CA</emph> Mutations in Human Papillomavirus–Positive Oropharyngeal Cancer<alt-title><emph type=\"ital\">PIK3CA</emph> in HPV+ Oropharyngeal Squamous Cell Carcinoma</alt-title>","year":2013,"lang":"en","type":"article","venue":"JAMA Otolaryngology–Head & Neck Surgery","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Hospital","funders":"","keywords":"Sanger sequencing; Mutation; Gene; Cancer; Oncogene; Head and neck squamous-cell carcinoma; Polymerase chain reaction; Human papillomavirus; Cancer research; Genotype; Stop codon; Molecular biology; Biology; Head and neck cancer; Medicine; Genetics; Internal medicine; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003498388,0.0001413412,0.0002136882,0.0008773939,0.0002992883,0.0004254808,0.0003264224,0.0003753173,0.004414326],"category_scores_gemma":[0.001290221,0.0002143778,0.0001455437,0.0008682535,0.0004980725,0.0002429563,0.0002923027,0.000240099,0.0006023441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003397418,"about_ca_system_score_gemma":0.000321888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002810677,"about_ca_topic_score_gemma":0.004862636,"domain_scores_codex":[0.9995838,0.00006860027,0.00005826128,0.0001267498,0.0001093838,0.00005325726],"domain_scores_gemma":[0.9986988,0.000299889,0.0006013669,0.00009954352,0.0001404949,0.0001598521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001939405,0.00001303712,0.9901545,0.00004065422,0.00002144821,0.000972906,0.00007480288,0.0000331913,0.006180217,0.00001852739,0.0002040112,0.002092732],"study_design_scores_gemma":[0.00001313007,0.00008194906,0.9914175,0.0000076882,0.00003130395,0.005144945,0.0001729842,0.0001090716,0.002632847,0.00002100858,0.0003622463,0.000005345834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999078,0.0001503842,0.00008208094,0.00002391185,0.00000204306,0.000008622405,0.00023663,0.000007829032,0.0004103648],"genre_scores_gemma":[0.9994715,0.00006166714,0.00006952864,0.00001971386,0.000003986866,0.000003548522,0.0001904186,0.000004370531,0.00017542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004414326,"threshold_uncertainty_score":0.01476735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403106833917789,"score_gpt":0.2564929254749554,"score_spread":0.2424618571357776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}