{"id":"W1527262512","doi":"10.1080/15384101.2014.1000182","title":"Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis","year":2015,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"Deutsche Forschungsgemeinschaft","keywords":"Biology; Origin recognition complex; Mitosis; Cell biology; Centrosome; Chromatin; Licensing factor; DNA replication factor CDT1; Cell cycle; Control of chromosome duplication; Genome instability; Pre-replication complex; DNA replication; Genetics; Eukaryotic DNA replication; Cell; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025651,0.00004490123,0.00004906422,0.00001485477,0.00002134761,0.000005827116,0.0000564956,0.00005938511,0.00000259126],"category_scores_gemma":[0.00003193268,0.0000385652,0.00001910737,0.00004339338,0.00002308163,0.000002967133,0.00005280556,0.0000249754,8.572533e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001083543,"about_ca_system_score_gemma":0.00001657414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000733182,"about_ca_topic_score_gemma":0.00009410768,"domain_scores_codex":[0.9995844,0.0000357161,0.0001054393,0.0001552104,0.00006097721,0.00005828874],"domain_scores_gemma":[0.9995427,0.000002486122,0.00007406718,0.000321612,0.00003519891,0.00002398636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006732511,0.00001708963,0.03709949,0.000006524076,0.000001508544,4.448139e-8,0.000118859,0.00002514886,0.9620257,0.00002571066,0.0001131919,0.0005600133],"study_design_scores_gemma":[0.0002048504,0.00003544945,0.08944862,0.000006355538,0.000002797544,6.427351e-7,0.00004325567,0.0002598424,0.9088807,0.0002954336,0.0007785382,0.00004356067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988336,0.00007873619,0.0000815056,0.00004999623,0.00003956167,0.0001112658,0.000001972955,0.000004615696,0.0007987301],"genre_scores_gemma":[0.9991812,0.00000264451,0.0004762466,0.00002409675,0.0000311872,0.000002929003,0.00002675323,0.000007267442,0.0002477163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05314504,"threshold_uncertainty_score":0.1572643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174173078258599,"score_gpt":0.2479332392626259,"score_spread":0.230515931436766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}