{"id":"W1527321334","doi":"10.1186/ar1387","title":"Oral treatment with PD-0200347, an α(2)δ ligand, reduces the development of experimental osteoarthritis by inhibiting the chondrocytes metalloproteases and inducible nitric oxide synthase gene expression and synthesis","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; National Cancer Institute; Genentech; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Arthritis Society; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; Lupus Research Alliance; Wellcome Trust; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Lupus Research Institute; Biogen; Austrian Science Fund; Arthritis Foundation","keywords":"Osteoarthritis; Cartilage; Immunohistochemistry; Medicine; Pathology; Placebo; In vivo; Lesion; Matrix metalloproteinase; Nitric oxide synthase; Internal medicine; Nitric oxide; Anatomy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000202591,0.000345846,0.000367839,0.0004443482,0.000105024,0.0002920305,0.0004226801,0.0003200516,0.005549964],"category_scores_gemma":[0.0001454914,0.0001206278,0.0003011864,0.0001843585,0.0002428044,0.0001498993,0.0001319014,0.0005516123,0.0006959159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001880352,"about_ca_system_score_gemma":0.0002998904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005438077,"about_ca_topic_score_gemma":0.0007610792,"domain_scores_codex":[0.9999011,0.00002242052,0.000009471761,0.00001542569,0.00003037683,0.00002133273],"domain_scores_gemma":[0.9999206,0.00001226359,0.00003514335,0.000005058068,0.000008408069,0.00001847935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02642793,0.00799014,0.003602629,0.00268269,0.0003178986,0.0002413332,0.0000684981,0.000840174,0.4771097,0.0004959691,0.006225256,0.4739979],"study_design_scores_gemma":[0.02141059,0.2005699,0.06723413,0.000707685,0.0009657131,0.002069839,0.0001966375,0.004036629,0.6451798,0.0007258978,0.05682506,0.00007808537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539402,0.03277646,0.003918307,0.0008801036,0.0004311634,0.0003258794,0.001251858,0.0006897814,0.005786396],"genre_scores_gemma":[0.9765335,0.01250379,0.00288132,0.0003178836,0.0001757624,0.0003286538,0.000874486,0.00001744121,0.006367205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005549964,"threshold_uncertainty_score":0.01856649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04752799260696476,"score_gpt":0.3177911800144631,"score_spread":0.2702631874074983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}