{"id":"W1527321334","doi":"10.1186/ar1387","title":"Oral treatment with PD-0200347, an α(2)δ ligand, reduces the development of experimental osteoarthritis by inhibiting the chondrocytes metalloproteases and inducible nitric oxide synthase gene expression and synthesis","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; National Cancer Institute; Genentech; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Arthritis Society; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; Lupus Research Alliance; Wellcome Trust; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Lupus Research Institute; Biogen; Austrian Science Fund; Arthritis Foundation","keywords":"Osteoarthritis; Cartilage; Immunohistochemistry; Medicine; Pathology; Placebo; In vivo; Lesion; Matrix metalloproteinase; Nitric oxide synthase; Internal medicine; Nitric oxide; Anatomy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007143211,0.0003225441,0.0004694738,0.0001976897,0.001012068,0.0001432015,0.000136422,0.0001071956,0.00003961719],"category_scores_gemma":[0.0001288879,0.0001811297,0.00005581231,0.0003639667,0.0006263676,0.0003188428,0.0001495433,0.000248114,0.000006802067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336323,"about_ca_system_score_gemma":0.0003334178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003182744,"about_ca_topic_score_gemma":0.0002688231,"domain_scores_codex":[0.9973198,0.0002663314,0.0004185915,0.000606033,0.0007990574,0.0005902073],"domain_scores_gemma":[0.9987634,0.0002867793,0.0001049664,0.0003713114,0.0001589535,0.0003145486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004455168,0.0006293036,0.0002793947,0.00001637425,0.00005104343,0.0001074174,0.001835691,3.587987e-7,0.8058691,0.00003092481,0.000009526169,0.1907253],"study_design_scores_gemma":[0.006427775,0.004748529,0.0001972926,0.0009988961,0.00004401521,0.0004833982,0.008989198,0.000001476694,0.9775099,0.00005518999,0.0003472544,0.0001970292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673639,0.03041095,0.000009375566,0.000306746,0.00001647969,0.001617056,0.00003986382,0.00003956574,0.000196054],"genre_scores_gemma":[0.9907444,0.002067099,0.005794233,0.0000263092,0.00005015407,0.001075583,0.00003962804,0.0000485916,0.0001540695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1905283,"threshold_uncertainty_score":0.7784108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04752799260696476,"score_gpt":0.3177911800144631,"score_spread":0.2702631874074983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}