{"id":"W1527439723","doi":"10.18632/oncotarget.4105","title":"Catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression","year":2015,"lang":"en","type":"article","venue":"Oncotarget","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada","keywords":"Androgen receptor; Prostate cancer; Enzalutamide; LNCaP; Cancer research; Medicine; Cell growth; Cancer; Biology; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002881832,0.0001323158,0.000237517,0.00005876729,0.0001214306,0.00001665506,0.00007129084,0.00005678058,0.0000498328],"category_scores_gemma":[0.00005069937,0.00007183967,0.00004395703,0.0001826475,0.0001943001,0.00009797695,0.0001059087,0.0001456349,0.000005555753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001090207,"about_ca_system_score_gemma":0.0003211606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001799645,"about_ca_topic_score_gemma":0.00001187084,"domain_scores_codex":[0.9989005,0.0000465328,0.0002041381,0.000214783,0.0003752711,0.0002587925],"domain_scores_gemma":[0.9992852,0.00003550059,0.00008446415,0.0001936167,0.0001753721,0.0002258028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004123451,0.0008508943,0.6742018,0.0008002545,0.0004658309,0.0001213283,0.02211567,0.00003022611,0.2086276,0.0000417249,0.05880876,0.02981249],"study_design_scores_gemma":[0.006325061,0.00168673,0.003396948,0.000857453,0.0001685411,0.00002589069,0.00172823,0.0001870215,0.9225158,0.0001428788,0.0627263,0.0002391495],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835446,0.01059788,5.192892e-7,0.004420395,0.0001731402,0.0007703868,0.00005893024,0.00002430533,0.0004098368],"genre_scores_gemma":[0.9964742,0.0005960419,0.0001659247,0.0000760201,0.0001879072,0.0001202023,0.00008918185,0.0000213999,0.002269099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7138882,"threshold_uncertainty_score":0.2929537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02812540724146859,"score_gpt":0.3326202619359871,"score_spread":0.3044948546945185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}